11 Best Baby Formulas For Acid Reflux Relief In 2022


If your baby has gastroesophageal reflux (GER), you need the best baby formula for reflux to help treat it. GER is acid reflux that occurs in babies when the stomach contents flow back into the esophagus because of a malfunction in the lower esophageal sphincter. GER causes frequent vomiting and regurgitation in babies, which can tire them out.

It is normal for infants below 18 months to have GER. However, you should consult a pediatrician if your baby suffers from severe reflux. Once the doctor rules out GERD, you can use an anti-reflux baby formula to ease out your baby’s constant regurgitation and vomiting (1). Here is a list of baby formulas you can try.

Our Top Picks

11 Best Baby Formulas For Reflux

1. Best For Baby’s Immune System: Enfamil A.R. Infant Formula

Enfamil A.R offers a gentle milk-based formula. This formula for acid reflux helps build your baby’s immune system, provides complete nutrition for their growth, and supports their digestive health. The rice starch and maltodextrin contents give a thicker consistency to reduce spit-ups and flow through the standard nipple bottles easily.

Enfamil A.R is a pediatric recommended brand that has been clinically proven to reduce spit-ups by over 50% in one week without causing any nutritional imbalance. It meets the AAP reflux reduction guidelines and is suitable for babies up to 12 months. Check out the review of this product for more information.


  • Pre-thickened with rice starch
  • DHA for brain and eye development
  • Filled with iron, probiotics, and vitamins
  • Cow milk protein
  • SNAP (Supplemental Nutrition Assistance Program) eligible


2. Best For Digestive Health: Gerber Good Start SoothePro Infant Formula

Made with probiotic L. reuteri and HMO, Gerber Good Start soothepro can give complete nutrition and comfort as breastmilk and supports digestive health and immunity. Its prebiotic and probiotic ingredients provide extra comfort for babies experiencing gastrointestinal symptoms, such as excessive colic, crying, fussiness, and gas. The packaging comes with a specially designed lid, which locks in the freshness and makes it easier to scoop the powder. Gerber soothepro is ideal for babies up to 12 months without lactose intolerance or allergies.


  • Probiotic L.reuteriis proven to reduce crying time by 50%
  • Enzymatically hydrolyzed whey protein is easily digestible
  • Lactose and ironhelps reduce gas and fussiness
  • DHA for brain and eye development
  • Contains HMO, found in breast milk
  • Non-GMO ingredients


3. Best DHA And Calcium Content: Similac Pro-Total Comfort Infant Formula

Similac pro-total comfort, made with non-artificial growth hormones, is an ideal and healthy reflux formula for babies. Its palm olein oil-free formula allows more efficient absorption of DHA and calcium and helps with softer stools. Similac pro-total contains easily digestible cow’s milk protein, which works well on babies suffering fussiness, gassiness, and crying. It is not for babies with galactosemia and protein allergies.


  • Contains 2′-FL HMO prebiotic for immune development
  • Hydrolyzed whey protein for easy digestion
  • DHA, lutein, and vitamin E for brain and eyesight development
  • Non-GMO baby formula
  • Eligible for SNAP benefits


4. Best For Preterm Infants: Organic Gelmix Infant Thickener and Formula

Certified USDA organic and Kosher organics, this is a hypoallergenic infant thickener and formula. This acid reflux formula uses organic tapioca maltodextrin, organic carob bean gum, and calcium carbonate for thickening instead of starch and xanthan gum.  This tasteless, odorless, smooth powder is a healthier alternative that does not break amylase protein in breast milk, unlike cereal and starch thickeners. Gelmix is easily digestible and helps maintain the infant’s natural nutritional balance. It is safe if they are preterm infants and less than six pounds. If you want to know more about the benefits of this product, check out this quick review on YouTube.


  • Free of corn, whey, gluten, soy, and dairy
  • Thickener for breast and formula milk
  • Does not contain starch or cereal thickeners
  • GMO-free formula
  • Made for infants weighing over six pounds


5. Best For Infant’s Overall Growth: Similac Sensitive Infant Formula

Similac sensitive infant formula is packed with essential nutrients for an infant’s overall growth, brain and eye development. This formula also contains prebiotics that helps strengthen your child’s immune system.  The formula helps reduce fussiness and excessive spit-ups caused by sensitive stomachs and lactose sensitivity. It comes in a powder form and a ready-to-use liquid and is ideal for babies without galactosemia up to 12 months.


  • Milk protein isolate for lactose sensitivity
  • OptiGro formula with DHA, lutein, and vitamin E
  • Corn syrup as a thickener
  • No palm olein oil
  • GMO-free


6. Best For Colic Relief: Enfamil Nutramigen Baby Formula

Enfamil Nutramigen is gentle, lactose-free, and hypoallergenic. The formula helps enhance the babies’ digestive health and immune system. The extensively hydrolyzed protein and corn syrup solids work as a treatment for milk protein allergies by being easily digestible, improving the digestive system, and promoting immune system balance. It does not use sucrose as its carbohydrate source and does not contain any artificial growth hormones. This pediatric recommended brand can reduce asthma and eczema allergies.


  • Enflora™ LGG® probiotics for good digestive health
  • DHA and ARA aidbrain and eye development
  • No artificial growth hormones
  • Fast relief from colic within 48 hours
  • Clinically proven


7. Best For Babies Up To 12 Months: Mama Bear Gentle Baby Formula

The gentle baby formula contains nutrients, including DHA, choline, lutein, prebiotics, and probiotics commonly found in breast milk to support your baby’s overall growth and brain development. It also contains minerals and vitamins that help strengthen their immunity. The formula uses partially hydrolyzed whey protein and corn syrup for easy digestion and lactose sensitivity. This is Kosher-certified by the Orthodox Union and is ideal for newborns up to 12 months.


  • GMO- and gluten-free
  • No artificial growth hormones
  • Contains nutrients found in breast milk
  • Partially hydrolyzed whey protein for easy digestion
  • Helps reduce fussiness and crying


8. Best To Fight Harmful Bacteria: Mama Bear Soy-Based Powder Infant Formula

Mama Bear soy formula along with iron can provide complete nutrition, improve digestive health and reduce discomfort in your little one’s tummy. It also contains minerals and prebiotics that support healthy bacteria and strengthen the baby’s immunity to fight harmful bacteria. This formula can be used for babies from birth to 12 months.


  • 100% soy protein for lactose sensitivity
  • Contains DHA, ARA, and lutein for brain and eye development
  • Has over 25 vitamins and minerals
  • Gluten- and lactose-free formula
  • Kosher-certified and FDA-regulated


9. Best To Reduce Fussiness: Enfagrow Gentlease Baby Formula

Enfagrow gentlease formula is a nutritious formula that helps babies transition into toddlerhood. It contains broken-down non-fat milk and whey protein solids that are easy to digest and help reduce fussiness, colic, baby gas, and crying. The formula uses DHA for brain development, probiotics, vitamin C, zinc for immunity boost, and over 30 nutrients for overall growth and development.


  • For toddlers between 9 to 18 months
  • Contains hydrolyzed non-fat milk and whey proteins
  • 17mg DHA per 100 calories aidfaster brain development
  • Consists of over 30 nutrients
  • Non-GMO formula
  • No artificial sweeteners, colors, or preservatives


10. Best Non-GMO Ingredients: Earth’s Best Organic Gentle Infant Powder Formula

Earth’s Best offers a gentle, organic formula to help reduce crying, fussiness, and gas. With DHA and ARA fatty acids, prebiotics, and lutein, this formula supports your little one’s brain and eye development, digestive health, and immunity. The formula meets FDA’s nutrition requirements and is ideal for babies with sensitive stomachs or other tolerance issues until they are 12 months.


  • Partially hydrolyzed whey protein and lactose
  • Certified USDA organic
  • Lutein for improved eyesight
  • Iron-fortified for red blood cell development
  • Non-GMO ingredients


11. Best For Toddlers: Baby’s Only Organic Toddler Formula

Baby’s Only toddler formula is made without growth hormones, GMO ingredients, antibiotic treated cow milk, harmful pesticides, or fertilizers. The formula contains DHA, ARA, iron, vitamins, and other minerals to provide the complete nutrition necessary for an infant’s development. It is a Kosher-certified formula suitable for toddlers.


  • Certified USDA organic
  • Lactose protein from the non-fat milk
  • Uses organic brown rice syrup for carbohydrates
  • Suitable for ages between one and three
  • Non-GMO ingredients


The information given in this section has been taken from manufacturers’ sources. MomJunction is not responsible for any of the claims made here. We recommend readers’ discretion.

How To Choose The Right Baby Reflux Formula?

Here are some factors to keep in mind while buying a baby reflux formula. Also, check with your baby’s pediatrician before choosing one.

  1. Ingredients: Formulas should contain a certain percentage of protein, fats, carbs, and a particular profile of vitamins and minerals specified by the FDA. Some formulas may also contain probiotics, DHA, AHA, iron, etc., to provide extra health benefits. It is vital to check the ingredients list and choose a formula depending on their nutrition needs.
  2. Type: Cow’s milk-based, hydrolyzed, specialized, and soy formula are the four types of reflux formulas. If your baby has lactose intolerance or protein allergies, the hydrolyzed formula is ideal. If not, they can choose between cow’s milk and soy formula. Specialized formulas are for babies with specific medical needs.
  3. Form: Formulas come as powders, concentrated, and ready-to-use liquids. Powder formulas and concentrated liquid formulas are mixed with water, whereas ready-to-use ones come pre-mixed and do not require additional water.
  4. Accessibility: You may need reflux formulas up to your baby’s first 12 months, so choose one that is easily accessible at local or online stores.

Why Trust MomJunction?

We have compiled this list of the best baby formulas for reflux after carefully studying the users’ requirements, the safety of the product, and its constituents based on user reviews and product forums. We have also reviewed the feedback from various trustworthy sources and chosen the products that will best suit your needs. A buying guide has also been prepared to help you confidently make an informed decision.

The options listed here for the best baby formulas for reflux have been chosen after carefully studying the users’ requirements as well as the safety of the product ingredients so that you can relieve your baby’s vomiting issues. These formulas are good for babies’ immune systems and promote digestive health while reducing the chances of spit-ups. This is a great way to make your little one’s life more comfortable, so make sure you consider their needs and pick the most suitable option.


MomJunction's articles are written after analyzing the research works of expert authors and institutions. Our references consist of resources established by authorities in their respective fields. You can learn more about the authenticity of the information we present in our editorial policy.
1. Infant Formula; Nina R. O’Connor MD Chestnut Hill Family Practice Residency Philadelphia Pennsylvania

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Vibha Navarathna

Vibha is a coder turned content writer. She holds a Masters degree in Computer Applications from Osmania University, Hyderabad and a certificate in 'Introduction To Child Psychology'. Her passion for writing fresh and informative content made her a full-time writer. Holding certifications in content writing and creative writing, she writes on electronics, baby and health products for MomJunction. Apart from... more