15 Best Diaper Rash Creams In 2022 To Reduce Skin Irritation

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The best diaper rash creams help you deal with your baby’s rashes effectively. Diaper rash cause much discomfort and irritation to your baby. Hence, to keep your baby happy in nappies, it’s important to take care of their hygiene.

If picking the right diaper rash cream sounds confusing, here is a list of the best ones we have carefully curated for you. These provide good relief against diaper rashes. But before you purchase one, let’s understand what causes rashes in the first place. Read on.

Our Top Picks

15 Best Diaper Rash Creams

1. Best For Sensitive Skin: Aquaphor Baby Healing Ointment

Aquaphor Baby Healing Ointment

Are you looking for a multipurpose cream? Bring home the baby healing ointment by Aquaphor. It’s an excellent diaper rash cream with multipurpose usage – it can be used for chaps, minor cuts, and skin dryness. This diaper cream is pediatrician-recommended and hypoallergenic, which means it is ideal even for babies with sensitive skin.


  • Active ingredient is petroleum jelly
  • Forms a protective barrier against the skin
  • No paraben-based preservatives
  • Free of dye and added fragrance
  • Includes panthenol, a derivative of vitamin B5
  • Heals healing the skin faster


  • May have a sticky consistency
  • May not absorb quickly

2. Best Organic: Babyganics Diaper Rash Cream

 Babyganics Diaper Rash Cream

Give this organic rash cream by Babyganics a try. It is made from organic plant materials. The cream contains a natural blend of plant-based oils and fats such as cocoa butter, almond oil, and shea butter. These materials help form a protective barrier on the skin. 15% zinc oxide content relieves from inflamed and sore skin due to diaper rash.


  • Petroleum- and cruelty-free
  • Have no phthalates, parabens, sulfates, or mineral oil
  • Free of dyes and artificial fragrances
  • Irritation-free and comfortable


  • May have a watery consistency
  • Coverage may not be enough

3. Best Pediatrician-Tested Formula: Burt’s Bee Baby Diaper Ointment

 Burt’s Bee Baby Diaper Ointment

Protect your baby’s skin from diaper rash and reduce the chances of any future diaper rashes with this Burt’s Bee diaper ointment. It is enriched with Vitamin E and Almond oil. The ointment is made from nut and plant oils, which help heal a diaper rash gently. 40% zinc oxide content protects the skin while also hastening the healing of existing diaper rash.


  • 100% natural formulation
  • Pediatrician-tested formula
  • Hypoallergenic and thus ideal for babies with sensitive skin
  • Free of parabens, phthalates, SLS, and petrolatum (petroleum jelly)


  • Cream may be dense
  • May have a strong smell of the ingredients

4. Best For Daily Use: Desitin Maximum Strength Baby Diaper Rash Cream

Desitin Maximum Strength Baby Diaper Rash Cream

Creams with thick texture offer a great protective shield on the skin and prevent rashes. So does the Desitin Maximum Strength diaper rash cream. It has a mix of petroleum jelly and glycerin that helps the skin retain its moisture for a longer duration. 40% zinc oxide content repairs the skin and prevents further formation of diaper rash.


  • Hypoallergenic formula
  • Free of parabens, phthalates, and dyes
  • Dermatologist- and pediatrician- tested
  • Clinically proven to protect the baby’s skin for 12 hours
  • Safe enough for daily use


  • May have a slightly medicated smell
  • May feel sticky

5. Best For Rash Minimizing And Reduction: Weleda Diaper Care Cream

Weleda Diaper Care Cream

Give this water-based diaper cream by Weleda a try. It blends with natural organic plant oils that are mild and gentle on the skin. The zinc oxide protects against the moisture in the diaper region and minimizes the risk of a rash.


  • Free of artificial fragrances and dyes
  • Has no mineral oil-based compounds and preservatives
  • Dermatologist-tested
  • Safe for infants with sensitive skin
  • Soothes your baby’s skin
  • UEBT-certified ingredients


  • May have a thin consistency
  • May not be suitable for severe rash

6. Best For Bacteria And Fungi Protection: Boudreaux’s Butt Paste Diaper Rash Ointment

 Boudreaux's Butt Paste Diaper Rash Ointment

Give your baby quick relief from diaper rash discomfort with the Boudreaux’s Butt Paste diaper rash cream. The cream contains 40% zinc oxide that heals any diaper rash and soothes irritation. It also contains plant oils and petroleum jelly, which help provide optimum protection to the skin.


  • Works immediately on contact with the rash
  • Helps prevent wetness from affecting the deeper layers of skin
  • Protect the skin from bacteria and fungi
  • Free of preservatives, dyes, parabens, and talc
  • Clinically-tested formula


  • May have a slightly overpowering medicated smell
  • May not work for severe diaper rash

7. Best For Allergy-Prone Skin: California Baby Calming Diaper Rash Ointment

California Baby Calming Diaper Rash Ointment

Here is the California Baby Calming diaper rash ointment made from naturally-derived oils and plant fats. There are no added preservatives. The formula is specially made for infants with delicate and sensitive skin. It makes the cream ideal for babies with allergy-prone skin.


  • Contains zinc oxide to protect the skin from further damage
  • Heals inflammation
  • Has no raw mineral oils
  • Free of petroleum-based products
  • Soothes sensitive skin


  • May have a grainy consistency
  • Once opened, the cream may dry quickly

8. Best Synthetic Fragrance-Free Formula: Triple Paste Medicated Ointment for Diaper Rash

Triple Paste Medicated Ointment for Diaper Rash

A cream that offers both protection and healing properties will be of great benefit. Bring home the Triple Paste diaper rash cream formulated with a combination of zinc oxide and petroleum jelly to provide rash protection and heal. The cream also protects the skin from wetness.


  • Hypoallergenic
  • Fragrance- and preservative-free
  • Ideal for everyday use
  • Suitable for severe diaper rash


  • May not spread smoothly

9. Best For Hydration And Nourishment: Balmex Diaper Rash Cream

Balmex Diaper Rash Cream

Besides treating the rash, the Balmex diaper rash cream also hydrates your skin. It has a highly effective formulation that reduces diaper rash in just one diaper change. It deals with wetness, friction, and enzymes found in stools – the three leading causes of diaper rash among infants.



  • May have a scrub-like texture
  • May not offer smooth application

10. Best For Skin Protection: Honest Diaper Rash Cream

Honest Diaper Rash Cream

Creams with hypoallergenic formula are always safe for sensitive skin, and so is this Honest diaper rash cream. It is made entirely of plant-derived ingredients. The natural oils and zinc oxide in the cream form a protective barrier on the skin and prevent the formation of any further diaper rashes.


  • NSF-certified
  • Raw materials used are plant-based and organic
  • No petroleum or raw mineral oil products
  • Free of preservatives, parabens, and added fragrances
  • Soothes irritated skin
  • Not tested on animals


  • Consistency may feel runny
  • May not offer sufficient coverage

[ Read : Honest Company Diaper Rash Cream Review ]

11. Best For Chapped Skin: A+D Original Diaper Rash Ointment

 A+D Original Diaper Rash Ointment

The diaper rash ointment by A+D Original is a petroleum jelly-based formula that prevents irritation and forms a protective layer on the skin. It contains natural cod liver oil rich in vitamin A and D that provide additional benefits to the baby.


  • Pediatrician-recommended
  • Free of dyes, parabens, and phthalates
  • Effective against chapped, chafed, or cracked skin
  • Ointment is safe for daily use
  • Can be applied after every diaper change


  • May have an overpowering smell
  • May have a watery consistency in hot climates

12. Best For Newborns: Mustela 1.2.3. Diaper Rash Cream

Mustela 1.2.3. Diaper Rash Cream

Protect your little one from new diaper rashes and heal the existing one with the Mustela 1.2.3. diaper rash cream. This cream prevents, relieves, and treats the rashes. It is blended with 98% of natural-origin ingredients.


  • NEA-approved
  • Hypoallergenic formula with no added fragrance
  • Formulated for sensitive skin
  • Safe to use on newborns
  • Ideal for applying at night time


  • May not be thick enough
  • May not protect from wet diapers

13. Best Antibacterial And Anti-Fungal: Earth Mama Organic Diaper Cream

Earth Mama Organic Diaper Cream

Earth Mama rash cream is an entirely organic diaper balm made with oils of plants grown organically. The cream is manufactured as a purely natural remedy for the baby. It does not contain any chemical compounds, including petroleum products and zinc.


  • Non-GMO
  • Dermatologist-tested
  • Free of artificial fragrances and parabens
  • Has natural antibacterial and antifungal agents
  • Safe for use with cloth diapers


  • Quantity may not be enough for some
  • May leave residue

14. Best Rapid Relief From Rashes: Cetaphil Baby Diaper Cream

Cetaphil Baby Diaper Cream

Get instant relief from an existing diaper rash with the Cetaphil diaper cream. The cream contains organic calendula, which provides relief from existing diaper rash and minimizes the risk of any further rash formation. It contains zinc oxide, which helps in rapid relief from diaper rash. The added vitamin B5 and E help nourish the skin.


  • Dermatologist-tested formula
  • Hypoallergenic
  • Free of dyes and mineral oils
  • Safe for babies with delicate skin
  • Free of paraben-based preservatives


  • May have an oily consistency
  • May stain clothes

[ Read : Cetaphil Baby Diaper Cream Review ]

15. Best Moisture Prevention: Grandma El’s Diaper Rash Ointment

Grandma El's Diaper Rash Ointment

Reduce chafing and irritation with Grandma El’s diaper rash cream. The petroleum and lanolin-based formula protects and softens the skin at the same time. The cream forms a barrier against wetness so that moisture does not enter the deeper layers of the skin.


  • Helps heal the skin that is damaged due to constant friction
  • Hypoallergenic formula
  • Works well for sensitive skin
  • Minimizes pain and soreness
  • Non-messy cream


  • May have a strong medicinal smell
  • May not be compatible with cloth diapers

For the best results from a diaper rash cream, it is important to observe some best practices.

What Causes Diaper Rash?

Diaper rash is any rash that occurs within the area covered by diapers, which includes the groin, buttocks, and parts of the inner thighs. Since diapers hold the excretions, several causes can contribute to a diaper rash. The following are the common reasons behind diaper rash in babies (1):

  1. Irritation: Stool and urine can combine to form ammonia, which can lead to a diaper rash.
  1. Bacteria: Stool contains a lot of bacteria. Leaving a soiled diaper for long can cause bacteria to invade the upper layers of skin and cause rashes. Staphylococcus is a common bacterium to cause diaper rashes in babies.
  1. Fungi: The moist environment within the diaper can be a perfect place for fungi to multiply. A common fungus to affect diaper area is yeast, also called candida.
  1. Diarrheal rash: Frequent excretion may cause the skin around the anal opening to get irritated and inflamed.
  1. Autoimmune rash: Conditions like psoriasis and eczema can also result in outbreaks in the diaper region. However, the symptoms will be a lot different to diaper rashes caused by infection or irritation.

The diaper rash cream you pick must be based on what is causing the rash.

[ Read : Chicco Nappy Cream Uses ]

How To Choose A Diaper Rash Cream?

Consider the following factors and criteria when picking a diaper rash cream:

  1. Look for zinc oxide: Zinc oxide is a common ingredient of many diaper rash creams. The compound forms a protective layer on the skin and prevents fecal bacteria, ammonia from causing rashes on the skin. If you want a diaper rash cream for long-term protection of your baby’s diaper area, then a diaper rash cream with zinc oxide will work great.
  1. Petroleum is good too: Petroleum jelly forms a protective barrier on the skin. Look for words like petrolatum, soft paraffin or just petroleum jelly on the ingredient list of diaper cream to determine if it has the compound in it.
  1. Oils: Many manufacturers use plant oils or fish oils as an alternative to petroleum jelly to moisturize the skin. Plant and animal oils will naturally contain vitamins that further nourish the baby’s skin.

Keep reading to find out what’s on our list of best diaper rash creams.

[ Read : Curatio B4 Nappi Cream Review ]

Tips For Diaper Rash Cream Usage

  1. Apply cream in a thick layer: Manufacturers and medical experts suggest that you should apply the diaper rash cream in thick layers for optimum protection (2). Clean the baby’s bottom, pat dry with a towel, and let it air dry for a while before applying the cream. Diaper cream brushes can also be used to apply the cream on the baby’s bottom with minimal mess.
  1. Try no diaper time: Let babies spend time without a diaper on to get their bottoms some air. Going without diapers for a few hours each day helps get rid of moisture, which causes a diaper rash. You can also consider using cloth diapers, which are breathable when compared to disposable diapers.
  1. Consult a doctor for severe diaper rash: If a diaper rash is severe or oozes white/clear liquid, then consult your doctor first. It could be a sign of severe fungal infection for which your baby will need medicated creams instead of a standard diaper rash ointment. Also, if diaper rash continues for more than three days after application of a regular diaper rash cream, then consult a pediatrician.

[ Read : Sebamed Baby Rash Cream Benefits / Uses ]

Diaper rash creams are useful when you have an infant who is still dependent on diapers. For the child’s safety, always read the instruction on the packaging of the diaper cream before usage. Time without diapers, good hygiene, and diaper cream are probably all that your baby needs to keep diaper rash away.

Why Trust MomJunction?

Vibha Navarathna is a keen product writer specializing in baby, nursing, and pregnancy products. Utilizing her experience as a mother, she has searched numerous websites to bring you this list of the best diaper rash creams for your baby. The creams listed here are gentle on the skin and offer certain healing properties. Keeping your safety concerns in mind, she has provided a detailed description of each one and also added a buying guide section for your convenience.

If diaper rashes leave your baby irritated and annoyed, it may be time to swap your regular baby creams with the best diaper rash creams. These are formulated specifically for your baby’s gentle skin and include nourishing ingredients that soothe and relieve rashes. When choosing the best cream for your little one, ensure it has ingredients such as petroleum jelly, zinc oxide, and plant oils or fish oils that protect the skin from bacteria while hydrating the skin. Further, ensure it is free of harsh chemicals such as phthalates, dyes, and parabens.


MomJunction's articles are written after analyzing the research works of expert authors and institutions. Our references consist of resources established by authorities in their respective fields. You can learn more about the authenticity of the information we present in our editorial policy.
1. Diaper Rash; Seattle Children’s Hospital
2. Diaper Rash; Brenner’s Children Hospital

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Vibha Navarathna

Vibha is a coder turned content writer. She holds a Masters degree in Computer Applications from Osmania University, Hyderabad and a certificate in 'Introduction To Child Psychology'. Her passion for writing fresh and informative content made her a full-time writer. Holding certifications in content writing and creative writing, she writes on electronics, baby and health products for MomJunction. Apart from... more