7 Best Enfamil Formulas For Sensitive Tummies In 2024

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Choosing the best Enfamil formula for your baby is a crucial decision that can impact their growth and development. Enfamil, a trusted name in infant nutrition, offers a range of formula options tailored to meet the nutritional needs of infants. In this article, we navigate the options considering factors such as ingredients, benefits, and suitability for different stages of development. Whether you are looking for a gentle formula for sensitive tummies or one enriched with essential nutrients, we’ve got you covered. So go through our curated list and discover the best Enfamil formulas and make an informed choice to provide your little one with optimal nutrition for a healthy start in life.

In This Article

What Types Of Formulas Are There?

There are several Enfamil formula types available to meet the different nutritional needs and requirements of infants. Here are some common types:

  • Cow’s milk-based formula: This is the most common formula made from cow’s milk that has been modified to resemble breast milk. These milk formulas are suitable for infants who do not have specific dietary restrictions or allergies.
  • Soy-based formula: Soy-based formula is made from soy protein and is intended for infants who are allergic to or cannot tolerate cow’s milk-based formulas. It is also an option for families who prefer a vegetarian or vegan formula.
  • Hydrolyzed formula: Hydrolyzed formulas contain proteins that are broken down into smaller pieces. They are often recommended for infants with a higher risk of developing allergies or who have difficulty digesting regular formulas.
  • Lactose-free formula: Lactose-free formulas are designed for infants with lactose intolerance, a condition in which they cannot properly digest lactose — the natural sugar in milk. These formulas contain alternative carbohydrates instead of lactose.
  • Specialty formulas: There are specialized formulas available for specific medical conditions or dietary needs, such as premature infants, infants with reflux or colic, or those with specific nutrient deficiencies.

It is important to consult a healthcare professional or pediatrician to determine the most appropriate formula type for your baby based on their needs and any specific dietary concerns or allergies.

7 Best Enfamil Formulas

1. Best For Gas Relief: Enfamil NeuroPro Gentlease Baby Formula

Enfamil NeuroPro Gentlease Baby Formula Image: Enfamil

Ensuring all-in-one comfort, the Enfamil NeuroPro Gentlease is specially formulated to help alleviate spit-up, fussiness, gas, and crying within 24 hours. It contains expert-recommended DHA for optimal brain development and an exclusive HuMO6 immune blend, providing support for the immune system. This gentle baby formula is designed for infants up to 12 months and offers essential nutrition with easily digestible proteins. Watch this YouTube review of the powder formula to make an informed decision.


  • Can decrease spit-up within a week
  • Formulated for lactose sensitivity
  • Suitable for sensitive stomachs
  • Recommended by pediatrician
  • Non-GMO formula


  • May not have a pleasant smell
  • May not suit every child
protip_icon Pro Tip
If your newborn depends on formula and does not consume breast milk, it is recommended that you feed them every two to three hours.

2. Best For Immune Health:Enfamil NeuroPro Baby Formula

Enfamil NeuroPro Baby Formula Image: Enfamil

The Enfamil NeuroPro formula contains DHA, which is expert-recommended for optimal brain development. It incorporates an exclusive HuMO6 immune blend, supporting the immune system. Further, it contains a triple prebiotic blend of 2’FL HMO, PDX, and GOS, ensuring adequate immune support. If you’re looking for a formula by Enfamil closest to breast milk, this formula with brain-building nutrition should be your choice. Here’s a video that demonstrates the features of the baby formula powder.


  • Formulated for ages nine months to five years
  • Softens stool and eases gas and colic
  • Good for brain and eye development
  • Strengthens the nervous system
  • Has essential vitamins


  • Quantity might be lesser than expected
  • May cause constipation in some
protip_icon Remember
When shopping for vegan formulas, ensure your product has a “vegan” or “plant-based” label, as several soy-based formulas may still contain animal byproducts.

3. Best DHA Formula:Enfamil Enspire Infant Formula

Enfamil Enspire Infant Formula Image: Enfamil

This Enfamil Enspire Optimum formula for newborns enhances immune health, as it features lactoferrin derived from colostrum. While the key ingredient lactoferrin aids in strengthening the immune system, it also contains DHA, which has been proven to support brain growth (1). With a specifically formulated blend of dual prebiotics, the formula aids in digestive well-being and bolsters the immune system.


  • Devoid of GMOs
  • Provides comprehensive nourishment
  • Formulated for children up to 12 months old
  • Closest to breast milk
  • Contains vitamins D, C, and E


  • May cause constipation in some
  • Smell may not be pleasant
protip_icon Pro Tip
It is recommended that you opt for FDA-approved baby formula to ensure it is completely safe for your baby to consume.
Enfamil NeuroPro Gentlease Baby Formula
Best For Gas Relief
Enfamil NeuroPro Baby Formula
Best For Immune Health
Enfamil Enspire Infant Formula
Best DHA Formula

4. Best Prebiotic Blend:Enfamil Reguline Baby Formula

Enfamil Reguline Baby Formula Image: Enfamil

If you’re looking for the best Enfamil formula for constipation, Reguline is formulated with easy-to-digest proteins. The prebiotic blend promotes the production of soft stools and comfortable passage within the first week of usage. This gentle baby formula helps meet your baby’s nutritional needs throughout their first 12 months. Further, it is enriched with omega-3, DHA, and choline for optimal brain development, prebiotics and vitamins to strengthen the immune system, and 30 essential nutrients to ensure a balanced diet. This video provides in-depth insights into this formula to help you make the right choice based on your requirements.


  • Recommended by several pediatricians
  • Qualifies to be purchased through SNAP benefits
  • Has a dual-prebiotic blend that works in the gut to feed good bacteria
  • Contains vitamins A, C, and E


  • May not be digestible by everyone

5. Best For Preemies:Enfamil NeuroPro EnfaCare High Cal Premature Baby Formula

Enfamil NeuroPro EnfaCare High Cal Premature Baby Formula Image: Enfamil

The Enfamil NeuroPro formula for preemies is a milk-based baby formula powder with a concentration of 22 calories per fluid ounce, enriched with essential nutrients. With a combination of vital nutrients, including vitamin D, omega-3, DHA, and vitamin C, the milk formula supports healthy growth in terms of length and lean body mass. It has a carefully crafted blend of ingredients to support the baby’s immune system and can facilitate catch-up growth in preterm babies.


  • Expert-recommended
  • Offers essential nutrition for brain development
  • Inspired by the composition of breast milk
  • Supports bone development
  • Non-GMO


  • Cannot be mixed with calories
  • May cause gas in some

6. Best Hypoallergenic Formula:Enfamil Nutramigen Infant Formula

Enfamil Nutramigen Infant Formula Image: Enfamil

If your little one experiences an allergy from consuming cow milk, you need a hypoallergenic formula like this one. Its key ingredient includes extensively hydrolyzed proteins that are less likely to cause an allergic response. The formula offers relief from colic and associated discomfort, starting as early as the first feeding. Additionally, it contains LGG — the most extensively studied probiotic for managing allergies and promoting your baby’s digestive health (2). Watch this video to decide whether the formula will be a suitable choice for your little one.


  • Lactose-free and gentle formula
  • Enriched with omega-3, ARA, choline, and DHA
  • Supports the immune system and brain development
  • Easy transition between breast milk and formula milk
  • Recommended by experts


  • May not be suitable for sensitive babies

7. Best Nutritional Formula: Enfagrow Premium Gentlease Toddler Nutritional Drink

Enfamil Enfagrow Premium Gentlease Toddler Nutritional Drink Image: Enfamil

Specifically created for children aged one and older, this formula contains 26 milligrams of omega-3 DHA to support brain development and promote rapid growth. Enfagrow Premium Gentlease formula features partially broken-down and easy-to-digest proteins, that help alleviate fussiness, gas, and crying. It also contains a proprietary blend of baby probiotics, immune-supporting vitamins, and 22 essential nutrients to support overall growth and provide everyday nutrition.


  • Fortified with expert-recommendations
  • Contains iron
  • Contains vitamin B12 and B6 hydrochloride
  • Formulated for sensitive stomachs
  • Includes essential minerals


  • May not have a pleasant taste
*The prices provided in this article are based on the latest available information. However, they may vary due to changes in pricing by the seller and/or promotional offers.

How To Choose The Right Enfamil Formula?

When choosing the best Enfamil formula for your baby, there are several factors to consider. Here are some guidelines to help you make an informed decision:

  1. Age and developmental stage: Enfamil offers different formulas tailored to specific age groups, such as newborns, infants, and toddlers. Choose a formula that corresponds to your baby’s age or developmental stage.
  2. Nutritional needs: Consider any specific nutritional needs or requirements your baby may have. For example, if your baby is allergic to cow’s milk or requires a lactose-free or organic formula, you may opt for a specialized formula. If your baby needs extra brain-building nutrients, formulas with added DHA may be beneficial.
  3. Consult your pediatrician: It’s always a good idea to consult your pediatrician before choosing a formula. They can provide valuable guidance and recommend the most suitable formula for your baby’s needs.
  4. Read labels and ingredients: Take the time to read the labels and ingredient lists of different Enfamil formulas. Look for formulas with high-quality ingredients that align with your preferences and your baby’s dietary requirements and restrictions.
  5. Allergies and sensitivities: Select a hypoallergenic formula if your baby has known allergies or sensitivities. Most of these formulas are designed to be gentler on sensitive tummies.

Why Trust Momjunction?

Vibha Navarathna demonstrates expertise in curating content focused on products designed for children and teenagers, specifically emphasizing those with high nutritional value. She conducts thorough product reviews by adopting a comprehensive approach. In this article, she presents a meticulously researched compilation of the top Enfamil formulas for babies. Each product has undergone careful evaluation, considering its nutritional value and ingredients.

Frequently Asked Questions

1. Which Enfamil formula is closest to breast milk?

The Enfamil formula closest to breast milk is Enspire. It is formulated to provide the essential nutrients and benefits found in breast milk, including lactoferrin and milk fat globule membrane (MFGM), which are important components for infant development.

2. What is the best Enfamil formula for babies with gas?

Enfamil Gentlease is often recommended as the best Enfamil formula for babies with gas. It is specifically formulated to be gentle on a baby’s digestive system, helping to reduce fussiness, gas, and crying. Enfamil Gentlease contains partially broken-down proteins that are easier to digest, reducing the likelihood of gas and discomfort.

3. How long can I give Enfamil formula?

The Enfamil formula is typically suitable for infants and children up to 12 months of age. Enfamil offers a range of formulas tailored to different infancy stages, from newborns to toddlers. As your baby grows, their nutritional requirements change and it is important to transition to the appropriate formula based on their age and developmental stage. However, it is recommended to consult your pediatrician to ensure you opt for the most suitable formula for your child’s specific needs.

4. Is Enfamil good for babies?

Yes, Enfamil is a well-known and reputable infant formula brand that is considered good for babies. Enfamil offers a range of formulas, and Enfamil formulas undergo rigorous quality control measures to meet the nutritional standards set for infant formula. However, since each baby is unique, what works well for one baby may not work the same for another.

5. Is Enfamil easy to digest?

Enfamil offers several formulas created to be easy to digest for babies. These formulas are formulated with partially broken-down proteins and other ingredients that are gentler on a baby’s developing digestive system. They aim to reduce common feeding issues such as fussiness, gas, and crying associated with digestion.

With a wide range of Enfamil’s best formulas available, choosing a formula tailored to address specific needs such as brain support, immune support, colic relief, and ease of digestion can help your child’s overall development. You can make a well-informed choice by considering your baby’s age, nutritional requirements, and specific concerns and consulting your pediatrician. Keep in mind that every baby is unique, and it might take some trial and error to find the best formula that works for your baby. Monitor your baby’s response to the formula and settle for a formula that your baby responds well to.

Infographic: What Goes Inside Enfamil Formulas?

Enfamil formulas are trusted infant formulas that provide essential nutrition for babies during their early development stages. With a range of options designed to meet specific needs, Enfamil formulas offer a balanced source of nutrients for growing infants. Explore the infographic below to learn more about the key nutrients incorporated in Enfamil formulas and their benefits for your baby’s well-being.

Key Nutrients Found In Enfamil formulas (infographic)

Illustration: Momjunction Design Team


MomJunction's articles are written after analyzing the research works of expert authors and institutions. Our references consist of resources established by authorities in their respective fields. You can learn more about the authenticity of the information we present in our editorial policy.
  1. A.Harrocks., Y.K Yeo; (1999); Health benefits of docosahexaenoic acid (DHA)
  2. L Cosenza., et al; (2015); Bugs for atopy: the Lactobacillus rhamnosus GG strategy for food allergy prevention and treatment in children
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