11 Best Ergonomic Mouses In 2021


If you use your computer all day for work, we recommend our list of the best ergonomic mouses to help you choose the right one. Ergonomic mouses come with a practical design that comfortably fits your fingers, wrist, and hands for easy use. It is important to choose the right mouse for daily work. An improper design can take a toll on your hand, wrist, and forearm.

A proper mouse and keyboard setup is essential to painful conditions like carpal tunnel syndrome, a weak grip, compression, and severe pain. However, choosing a mouse that suits your requirements can avoid inflammation caused by repetitive action and go a long way in protecting your hand and wrists. So, take a look at our list of ergonomic mouses that can prevent severe repercussions and help you work throughout the day without a worry.

11 Best Ergonomic Mouse

1. Anker 4G Wireless Vertical Ergonomic Optical Mouse

This scientifically designed ergonomic mouse assures a healthy and neutral wrist and arm position to experience less strain and a smoother movement with less overall pressure. Optical tracking technology of 800/ 1200/ 1600 DPI resolution boosts sensitivity and precise and smooth tracking on a wide range of surfaces, unlike a standard optical mouse. It features ‘next’ and ‘previous’ buttons for convenient browsing. It saves power as it automatically switches off after 8 minutes of being idle. Measuring 120 x 62.8 x 74.8 mm, this product weighs 3.4 ounces. This vertical ergonomic optical mouse features a 2.4G USB receiver at the bottom and combines functionality and comfort.


  • Easy access buttons
  • Customizable settings
  • Compatible with Windows 10/ 8/ 7/ Vista / XP / 2000
  • Fits the contour of your palm


  • The previous/next buttons are not recognized on the Mac OS X

2. Lekvey Vertical Wireless Ergonomic Mouse

This mouse has an ergonomic and sleek vertical design that places your wrist and arm in a neutral and healthy position and causes less strain. Its ‘page back’ and ‘page forward’ buttons make web browsing convenient. The sensitivity of this ergonomic wireless mouse can be easily adjusted at 800 /1200/1600 DPI. It has an in-built high capacity rechargeable battery making it easy to use and features a nano 2.4G USB receiver at the bottom. This mouse gives you the option of switching between wireless and a 78 cm charging cable effortlessly so that you never run out of power. This ergonomic mouse fits the contour of your palm perfectly for enhanced comfort. It features 6 buttons for more control over your computer and is an economical and effective solution to your computing needs. It weighs 95 grams and measures 5 x 3 x 2.5 inches.


  • Futuristic design
  • Recharge quick connect design
  • Reduces pain and discomfort
  • Compatible with Windows 2000 / XP / Vista / 7 / 8 / 10 / Linux


  • Not compatible with Mac OS, Apple products

3. Logitech MX Vertical Wireless Mouse

The ergonomic design of this vertical mouse places your hand at a 57° angle which is a natural handshake position. It thus dramatically reduces any pressure or strain on the muscles or tendons. This ergonomic wireless mouse features a high precision 4000 DPI for accurate tracking that reduces your hand movements 4 times. It can navigate with complete ease on 3 Windows or Mac computers and copy-paste files, text, and images from one to the other using Logitech FLOW. It features a wireless USB unifying receiver, USB-C charging cable, and Bluetooth smart technology. Its rechargeable battery stays powered for up to 4 months, and a 1-minute quick charge can give you up to 3 hours of use.


  • Adjustable DPI speed
  • Premium scroll wheel
  • Customizable shortcuts
  • Textured thumb area
  • Island keys
  • Cursor speed switch
  • United States ergonomic certified


  • Some feel the mouse buttons require too much pressure to push down

4. Kensington Vertical Wireless Ergonomic Mouse

Because of its angled slope, the form-fitting and natural contours of this mouse keep your hands in a neutral handshake position and give added support thanks to the extended rest for the little finger.  This ergonomic mouse improves the posture of your wrist and arm, reducing pressure and compression, and giving better muscle support and comfort. Measuring 2.74 x 4.38 inches, it has wireless connectivity through a  2.4GHz USB receiver, with a control range of 10 meters. Its plug-and-play USB-A nano receiver is kept safe when not in use in a storage compartment. It features a scroll wheel and 4 control buttons — right click, left click, forward, and back for web browsing. The DPI button helps you select multiple options of 800, 1200, 1600, 2000, 2400 to adjust the sensitivity as per your requirements.


  • Auto-sleep function
  • On/Off switch
  • Low battery indicator light
  • TAA compliant
  • No software or drivers needed
  • Compatible with Windows, MacOs, and Chrome


  • May not be suitable for larger hands because of its height

5. Delux Vertical Ergonomic Mouse – Wired with RGB

With the amount of time we spend on our computers, it is vital to have the optimal size vertical mouse so that you suffer absolutely no discomfort and strain. Keeping in mind that everyone has a different hand size, this brand offers you a range of sizes from small to large, including a product for left-handed people. This unique ergonomic mouse has an innovative volute bionic design to reduce muscular strain and hand stiffness. It features a thumb groove and rubber coating and a humanized wrist rest that is removable and protects your wrist from friction. It has a dotted switch to adjust the DPI between 800, 1200, 1600, 2400, and 4000 according to your working requirement, and 4000 DPI can even be used as an ergonomic gaming mouse.


  • RGB Floating light
  • 6 buttons— left and right click, forward, backward, DPI, on/off
  • Scroll wheel
  • Measures 87 x 3.74 x 3.90 inches
  • Weighs 7.4 ounces
  • Compatible with Windows XP, Vista, 7, 8, 10 operating system


  • Limited support to Mac

6. iClever Ergonomic Mouse – Gray Black

Give yourself the gift of ultimate comfort and prevent injuries like carpal tunnel syndrome with this ergonomic mouse that is thoughtfully designed. It has been innovatively designed to relieve pain and cramping in your wrists and features a thumb rest, side grips, and strategically placed buttons. Its DPI optical sensor can be adjusted between 4 resolutions of 1000, 1600, 2000, and 2400 depending on your needs and effortlessly responds to the minutest movements. This wireless mouse gets things done quicker with the in-built ‘next/ previous page’ buttons, where just a click will get you to the desired page. Its ultra-fast 2.4 GHz wireless connection ranges 49 feet so that you can work peacefully in a clutter-free workspace. The advanced stability of this ergonomic mouse makes each click inaudible and precise.


  • Sleek design
  • Matte finish
  • 4 GHz receiver
  • Auto power saving capability
  • Soundless and smooth scroll wheel
  • 3 months of battery life
  • Storage compartment for USB receiver
  • Compatible with Windows, Mac OS, Chrome OS, and Linux based operating systems


  • Some may find it heavy and bulky

7. ASOI ​​DOOMIER Wireless Vertical Ergonomic Mouse

As compared to a traditional mouse, this ergonomic mouse has a unique vertical design that supports the palm and keeps your arm and hand in a comfortable and natural position. This greatly relieves wrist pain and strain and pain and relaxes your arm muscles. Its efficient 2.4G wireless connection has a range of 33 feet, and its click is almost entirely soundless. The DPI of this mouse can be adjusted between 800, 1200, and 1600 as per the sensitivity you require and features 6 buttons, including the functional ‘page back’ and ‘page forward’ buttons for web browsing.


  • In-built rechargeable battery
  • Power saving mode after 8 minutes
  • Easy to use USB receiver
  • Perfect size for large and medium hands
  • Widely compatible with Windows 2000, XP, Vista, Windows 7, 8, 10, and Linux


  • Some may find the buttons hard to click

8. J-Tech Digital Ergonomic Mouse

Not only does this ergonomic mouse reduce strain in the wrist, hand, and arm with its handshake design, it also features forward and backward thumb buttons for added convenience. It works smoothly on almost all non-metallic surfaces, and its in-built 800 mAh lithium battery is fully rechargeable. Its detachable palm rest reduces drag and is both sweat and slip-resistant, making it all the more convenient to maneuver the mouse across most surfaces. Depending on your requirement, the sensitivity and responsiveness can be adjusted through the DPI of 800, 1200, 1600, or 3200. A 360° signal allows for full mouse movement, and its optical tracking technology allows precise tracking on a variety of surfaces due to its sensitivity.


  • RGB LED light
  • Includes a charging cable
  • Button functionality can be changed using third party software
  • Compatible with Windows 7, 8, 10, XP, Vista 7, 8, Linux, Mac OS


  • LED button is right next to thumb which makes it easy to click accidentally

9. Evoluent VM4SW Vertical Ergonomic Mouse

This practically designed ergonomic mouse offers gentle support to your right in a vertical neutral position. Its patented shape prevents your forearm from getting twisted and prevents muscle strain. Once you install the Evoluent Mouse Manager software on your computer, you can configure the various buttons of the mouse and change their function while also setting how the buttons work within different programs. The pointer speed can be adjusted from low to high with the optical sensor controls, and you don’t need to release the grip for speed adjustment. A broader lip at the bottom edge protects your little finger from constant friction, and the thumb area has been redesigned for ultimate comfort. It’s compatible with all USB operating systems, so you need to plug and play.


  • 2600 DPI
  • Wireless USB receiver
  • Measures1 x 3.2 x 3.2 inches
  • Compatible with Windows 7 and 10 Mac OS 10.5 to 10.14


  • Incompatible with Catalina OSX

10. KKUYI Ergonomic Mouse

This Bluetooth mouse features an ergonomic and scientific design to protect you from wrist pain and muscle strain by keeping your hand and arm in a vertical and comfortable position. Based on snail bionics and ergonomics, this ergonomic mouse lies on the side at 54° so that your arm is naturally stretched out and is not in a state of tension. It features a recharge quick-connect design so that you never run out of power as you can switch from wireless to a charging cable connection. The DPI can be adjusted between 800, 1200, and 1600 depending on the sensitivity you require. It also features a ‘back and forward’ button for convenient web page browsing. Its streamlined design features a premium quality rubber coating with high gloss details.


  • Wireless design
  • Plug and play
  • Intelligent auto-sleep mode
  • Lightweight and portable
  • Compatible with Linux, Android Windows 10, 8, 7, Vista, XP 2000, Mac OS X


  • The previous/next page buttons are not recognized on the Mac OS X

11. ECHTPower Ergonomic Mouse – 4G

If you are looking to reduce hand fatigue, wrist pain, and muscle strain, this is just the mouse for you. It comes fitted with a large capacity 1200 mAh rechargeable battery and can be used for up to 120 hours on a single charge. For charging, the USB receiver can be plugged into the device so the mouse can be used even if it is charging. It features a nano USB receiver at the bottom of the mouse with a range of 10 meters, and you can plug and play. Its automatic sleep mode gets activated after 8 minutes of inactivity and can be restarted by clicking any button. The DPI of this ergonomic wireless mouse can be adjusted at 1000, 1600, and 2400 depending on your requirement, and quick web browsing is facilitated by the ‘forward and back’ buttons.


  • Anti-skid pad at the bottom
  • Suitable for using on a variety of surfaces
  • Frequency of 2405MHz-2476MHz
  • Compatible with Windows XP, Vista 7, 8, 10, Linux and Mac OS X


  • The forward/back buttons are not available in Mac OS X

Now that you have been through our review of the 11 best ergonomic mouse, let us give you a few pointers to keep in mind so that you are able to pick one most suited to your requirements, and which will guarantee ultimate comfort.

How To Choose The Right Ergonomic Mouse

  • Size

Ideally, the size of the mouse should fit your hand comfortably. Your hand will not rest in the right place on the mouse, if it’s too large, and is prone to clinching if it’s too small, leaving too much gap between the mouse and your palm. Check the dimensions of your current mouse for a better perspective, before purchasing a new one.

  • Weight

The weight to a large extent depends on the size of the mouse. Even a few extra grams make a difference. You need to decide whether you prefer a lightweight mouse that is easy to push around, or the stability of a heavier mouse. Some brands come with a tuning set that you can either remove or add for the resistance and weight you desire. Always check the weight specifications of the mouse before buying it.

  • Wireless or wired

A wireless mouse definitely removes the clutter of an extra cable on your desk, but it requires batteries which are not exactly eco-friendly. It may also require a USB receiver to connect it to the computer which is easy to misplace, and needs to be ‘awakened’ after staying idle for a while. Consider these drawbacks before choosing either a wireless or wired mouse. The main demerit of a wired mouse is the extra cable, which becomes impractical when you’re working outside.

  • Form factor

This decides how ergonomic and comfortable your mouse will be. Most people find the traditional horizontal mouse the most comfortable and familiar for most people, but it’s a good idea to give a vertical or trackball mouse a try, especially if you can feel the early onset of tendonitis or carpal tunnel syndrome. A joystick mouse can be used by people with an existing RSI condition, as most people find it harder to maneuver and less precise than the other 3 kinds.

  • DPI switch

DPI, or dots per inch, is a switch that allows you to adjust the sensitivity of the cursor of your mouse without any software. The higher the DPI, the more sensitive the cursor, which will then respond to the minutest movements of the mouse. Gamers like to go for a mouse that is more responsive, and is supported with a higher DPI setting. Some studies do show a correlation between carpal tunnel syndrome and a high DPI, but a physical DPI switch lets you raise or lower your mouse’s sensitivity as required by the task at hand.

  • Number of buttons

Usually, every mouse has 2 primary buttons for right and left-clicking. Customizable extra buttons ensure that you don’t have to move the mouse for certain tasks, which reduces the chances of injuries. At the least, try to choose a mouse with back and forth browser buttons, as these are tasks that are performed frequently throughout the day.

  • Left or right handed

A computer mouse is usually designed for right handed people, though a few are ambidixoul, which means they can be used by both right and left handed people. This is good as you can distribute its use between both hands reducing the chances of injuries. An ambidixoul mouse is also worth considering if one of your hands is disabled.

  • Budget

When assessing the real cost of the mouse, don’t look at just the price— assess the warranty period as well. A mouse that costs more but has a long warranty period and a hassle-free return policy works out much better than a less expensive mouse that stops serving you in a couple of months. In any case, a mouse that is more comfortable, and has better productivity should be the deciding factor.

The computer mouse is a much-neglected product as we instead spend on the CPU, graphics card, or a PC case. But remember that along with the keyboard, the mouse is the only part of the computer that you are constantly touching. Unfortunately, neglecting this integral part of the system can have serious repercussions. If you want to avoid long-term problems like carpal tunnel syndrome, tendonitis, pain, damaged cartilage, and nerve pain, you should aim to get an ergonomic mouse that ensures the correct wrist position. We hope our review of the 11 best ergonomic mouses will help you find one that provides the comfort of your hand and wrist comfort and doesn’t allow your work to suffer too.

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Wedetso Chirhah

Wedetso Chirhah holds a masters degree in English Literature. He had written content for more than 15 B2B websites and edited school books before joining MomJunction as an editor. Wedetso ensures the articles meet the highest editorial standards. He enjoys making content understandable and relatable to readers, and he is a big fan of the versatile em dash. He also... more