Babies Born With Herpes: Causes, Symptoms And Prevention

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Congenital herpes or birth-acquired herpes infection is a viral infection acquired by babies during delivery or in the womb. Babies born with herpes may show symptoms of the infection at birth or may develop them shortly after birth. Pregnant women with genital herpes may transmit the virus to their babies during vaginal delivery.

Herpes infection can cause lifelong complications that can often be life-threatening if left untreated. Hence, this post tells you more about the causes, symptoms, diagnosis, complications, treatment, prevention, and outcomes of birth-acquired herpes in babies.

Causes Of Birth-Acquired Herpes

Herpes infection is a contagious viral disease caused by the following strains of herpes virus(1).

  • Herpes simplex type 1 (HSV 1) causes cold sores around or inside the mouth.
  • Herpes simplex type 2 (HSV 2) causes genital herpes infection.

Once infected, the herpes virus stays dormant within the body and may cause recurrent infection during favorable circumstances, such as low immunity. Infants can contract herpes from inactive (no symptoms) or active (having blisters in the birth canal) maternal herpes infection.

Note: Herpes contracted from cold sores after birth is considered a neonatal herpes infection and not a congenital herpes infection.

Signs And Symptoms Of Birth-Acquired Herpes

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Some babies may only have skin lesions during herpes infection. A few babies could develop systemic herpes infection, which affects various organs of the body. When the baby has herpetic lesions on the skin and systemic herpes infection, it is called disseminated herpes.

The following signs and symptoms are seen in congenital herpes infection (2).

  • Blisters (fluid-filled bumps) or vesicles on the skin
  • Lethargy
  • Breathing issues
  • Bleeding-related problems
  • Trouble feeding
  • Jaundice

Fluid-filled blisters are commonly seen around the eyes or on the torso in congenital herpes infection. The blisters can burst and crust over time. 

Diagnosis Of Birth-Acquired Herpes

The appearance of skin lesions helps diagnose herpes simplex infection in babies. The culture of a sample from the lesion helps confirm the diagnosis. Doctors may also check for enlarged lymph nodes in the groin and neck area.

Blood, cerebrospinal fluid, and urine analyses are often ordered if the baby has a herpes infection. An eye examination is recommended since eye herpes is common in birth-acquired herpes infection. MRI scan of the head is often ordered to check for brain swelling or brain damage, especially if the CSF analysis is positive for the herpes virus (3).

Treatment For Birth-Acquired Herpes

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The treatment involves mostly being supportive. It also depends on the symptoms the baby presents with. Intravenous antiviral medications, such as acyclovir (Zovirax), are recommended for infants with herpes for a few weeks (1).

Topical ophthalmic drugs are given along with systemic antiviral therapy for babies with herpes eye infections. An opthalmologist’s review will assist with a proper assessment.

Possible Complications Of Birth-Acquired Herpes 

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The following complications may occur in disseminated herpes virus infection.

  • Seizures
  • Eye inflammation
  • Blindness and vision issues
  • Respiratory problems
  • Shock
  • Hypothermia
  • Coma

Seizures, shock, and hypothermia can be due to brain herpes infection (Herpes encephalitis), and this may often result in brain damage.

Prevention Of Birth-Acquired Herpes

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The following precautions may reduce the risk of congenital herpes.

  • Taking antiviral medications during the last weeks of pregnancy to reduce the risk of transmission
  • Practicing safe sex during pregnancy

Prognosis Of Birth-Acquired Herpes

Skin lesions may reoccur even after the treatment. Babies with systemic herpes or encephalitis may have a poorer prognosis than babies with skin lesions. Although antiviral therapy may help subside active infection, herpes may come back if there are favorable conditions since the virus remains dormant in the body.

Disseminated congenital herpes can result in neurological issues or coma, which can be life-threatening. Babies with systemic herpes infection may develop other potential health problems based on the organ affected.

Frequently Asked Questions

1. How common is congenital herpes?

Neonatal herpes infection is estimated to affect between one in 3000 and one in 20,000 babies. The infection may be transmitted to the fetus inside the uterus or during childbirth through the infected genital tract (most common). Though less common, the newborn may acquire the infection from a parent or caregiver after birth via an infected mouth or hands (4).

2. Does my baby have herpes antibodies?

Maternal antibodies may be transferred to the newborn. A study suggests that women with pre-existing herpes infection have a complete immune response to the virus and may pass those antibodies to the baby. However, if the infection is acquired during pregnancy, maternal antibody production may not be enough to reach the baby and protect them from severe outcomes (5).

Herpes virus cannot be eliminated from the body, but babies born with herpes may be treated with antiviral medications and supportive therapy. Babies may contract the virus from active as well as dormant maternal infection. Untreated herpes infection may have life-threatening consequences such as shock or coma. Check with your doctor if the baby develops skin lesions, breathing trouble, or jaundice. Transmission of active herpes from mother to child may be prevented by avoiding vaginal delivery and antiviral treatment of the mother during late pregnancy.

Key Pointers

  • Congenital herpes is a condition where babies develop a viral herpes infection in the mother’s womb or during the birth process.
  • This infection might give rise to complications such as respiratory problems and seizures in newborns.
  • Talk to a pediatrician if your baby develops blisters or shows signs of fatigue, trouble breathing, and feeding.
  • Though we cannot eliminate the infection, it is manageable by antiviral medications.


MomJunction's articles are written after analyzing the research works of expert authors and institutions. Our references consist of resources established by authorities in their respective fields. You can learn more about the authenticity of the information we present in our editorial policy.
1. Congenital Herpes Simplex; The US National Library of Medicine
2. Birth-acquired Herpes; Johns Hopkins Medicine
3. Pregnancy and herpes; MedlinePlus; The US National Library of Medicine
4. Neil D. Fernandes; Congenital Herpes Simplex; NCBI
5. Dartmouth Researchers Find that Mothers’ Antibodies Against HSV-1 Can Protect Their Infants from the Virus; Dartmouth Geisel School of Medicine
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Dr Bisny T. Joseph

Dr. Bisny T. Joseph is a Georgian Board-certified physician. She has completed her professional graduate degree as a medical doctor from Tbilisi State Medical University, Georgia. She has 3+ years of experience in various sectors of medical affairs as a physician, medical reviewer, medical writer, health coach, and Q&A expert. Her interest in digital medical education and patient education made...
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Dr. Anisa Vahed

Dr. Anisa Vahed did her MBChB from Stellenbosch University in 2009 and specialization in Pediatrics & Child Health from the University of Cape Town in 2019. She also holds a Diploma in Child Health from The Colleges of Medicine of South Africa. She is a general pediatrician with experience in premature baby care. She currently runs her private practice in...
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