Circumoral Cyanosis In Newborns: Symptoms, Causes And Treatment

✔ Research-backed

Circumoral cyanosis is a type of cyanosis that occurs when there is discoloration around the mouth. Here, the term “cyanosis” describes a bluish discoloration or tint in the skin caused by various conditions related to blood circulation and reduced oxygen levels in the bloodstream.

Cyanosis affects different body parts, including the nails, fingers, earlobes, and mouth or mucous membranes (1), and can be divided into distinct categories depending on the discolored body parts.

Read on to know more about circumoral cyanosis in babies, including its symptoms, causes, diagnosis, and treatment options.

In This Article

What Is Circumoral Cyanosis?

Circumoral cyanosis is defined as the blue-gray discoloration around the mouth, especially the upper lip area. It is the most common type of cyanosis in babies and children. With dark skin, the tint may also appear gray or white (2).

Although the condition can be worrisome for parents, you may check a few things to rule out a medical emergency.

Main Categories Of Cyanosis

Let us now discuss the two main types of cyanosis (1) (3).

  • Central cyanosis: It occurs in the central part of the body, including the mouth, torso, and head. In newborns, this condition is not considered normal and is usually associated with low oxygen levels in the blood. Central cyanosis can also occur due to a problem in the heart, lungs, or blood. 
protip_icon Quick fact
Newborns may normally have central cyanosis up to five to ten minutes after birth. Then, it reverses as the oxygen saturation rises to 85 to 95 percent (12)
  • Peripheral cyanosis: It occurs in the extremities, including toes, fingertips, and hands. It can also occur in the circumoral area. This type of cyanosis is usually not life-threatening, but understanding the cause can help prevent further complications. 

What Causes Circumoral Cyanosis In Babies?

Circumoral cyanosis usually resolves when the body is warmed up.

Image: Shutterstock

Circumoral cyanosis is usually considered a type of acrocyanosis, which is common in babies as long as it doesn’t affect the central parts of the body (1). In some cases, children may develop acrocyanosis after a swim or bath in cold water. However, it resolves as soon as the body is warmed up.

However, in some cases, the condition does not go away even after warming up and may be due to underlying heart or lung problems, such as Tetralogy of Fallot, a type of congenital heart disease (4).

Cyanosis may also occur when the lungs do not properly oxygenate the blood or the body is not receiving enough oxygenated blood. It most commonly occurs (5):

Cyanosis may also occur if the baby is crying incessantly.

Image: Shutterstock

  • Immediately after feeding, bowel movement, or waking up
  • If the baby is dehydrated
  • If there has been smoke inhalation
  • If there is a foreign body obstructing the airway (choking) or suffocation (asphyxia)

According to a case report published in the American Academy of Pediatrics (AAP) publications, perioral cyanosis without signs of respiratory distress was seen in a baby with COVID-19 infection (6). Coexisting signs and tests may help diagnose the exact causes of cyanosis around the mouth in babies.

protip_icon Quick fact
In newborns, cyanosis around the mouth may last for about 24 to 48 hours (12).

Signs And Symptoms Of Circumoral Cyanosis In Infants

Babies with circumoral cyanosis may also experience fever.

Image: Shutterstock

Babies with circumoral cyanosis will have blue discoloration around their mouth. According to the Boston Children’s Hospital, blue discoloration around the mouth and face, earlobes, and fingernails are the common symptoms of cyanosis in babies (7).

You may also look out for the associated signs and symptoms in babies (8):

  • Respiratory issues – difficulty breathing, fast breathing, chest indrawing
  • Sweating
  • Fainting
  • Discomfort
  • Fever

When To See A Doctor?

See a doctor if the baby has experienced cyanosis for the first time.

Image: Shutterstock

If the cyanosis is visible on the lips, tongue, head, or torso, it is central cyanosis and should be immediately checked by the doctor (1).

Additionally, talk to your pediatrician or cardiologist

  • If your baby has experienced cyanosis for the first time
  • If the frequency of cyanosis increases, it may be due to a heart condition
  • If the cyanosis condition lasted for more than one minute

How Is Circumoral Cyanosis Diagnosed?

The three primary steps that your doctor may perform to diagnose circumoral cyanosis may include (1):

  • Medical history of the baby
  • Physical examination
  • Oxygen saturation level to determine whether the oxygen levels are low or normal

Depending on the above findings, the doctor may recommend further confirmatory tests or evaluation. Also, the urgency of the condition may warrant consultation with a heart or lung specialist or a visit to the emergency room.  

How Can Circumoral Cyanosis Be Treated?

In most cases, if the cyanosis is due to acrocyanosis, babies may not require any treatment. However, if there is an underlying heart or lung problem, the treatment may depend on the condition (1).

Frequently Asked Questions

1. Which congenital heart diseases are characterized by cyanosis at birth?

Congenital heart diseases characterized by cyanosis include valve defects such as (9) (10):

  • Truncus arteriosusiA congenital heart defect where the crucial arteries transporting blood from the heart are malformed
  • Tetralogy of Fallot
  • Tricuspid, Pulmonary or Aortic valve narrowing
  • Transposition of the great arteries
  • Total anomalous pulmonary venous return
  • Hypoplastic left heart syndromeiA severe condition characterized by malformation of the left side of the heart affecting the blood circulation process
  • Pulmonary valve atresiaiA congenital condition where the valve that regulates blood circulation from the heart to the lungs fails to develop
  • Ebstein's anomalyiA rare cardiac abnormality where the tricuspid valve (involved in the blood circulation) is positioned incorrectly
  • Complete interruption of the aorta

2. How are cyanosis and hypoxia related?

Hypoxia refers to the condition where body tissues have low oxygen levels. Cyanosis may be the clinical manifestation of tissue hypoxia (11)

3. Can anemia cause cyanosis?

Anemia plays a role in cyanosis but is not a common cause. A patient with severe anemia may not have cyanosis (11).

Circumoral cyanosis is evident by blue or gray discoloration around a baby’s mouth. It is considered a type of acrocyanosis caused by oxygen deprivation. In newborns, the condition usually resolves once circulation is established. Blue coloration around the mouth is not serious if it is not on the lips. It may fade once the baby is warmed up. However, seek immediate medical attention if you notice warning signs such as fainting, difficulty breathing, excessive sweating, and a bluish appearance around the head, torso, and tongue.

Key Pointers

  • Circumoral cyanosis refers to the blue or grayish discoloration around a baby’s mouth.
  • Respiratory issues, pain, and fever are common signs of circumoral cyanosis.
  • Spreading discoloration to the tongue, cheeks and other parts is a cause for concern.
  • In most cases, this condition resolves unless there is an underlying condition present.


MomJunction's articles are written after analyzing the research works of expert authors and institutions. Our references consist of resources established by authorities in their respective fields. You can learn more about the authenticity of the information we present in our editorial policy.
  1. Cyanosis in infants and children; Cincinnati Children’s
  2. J Bernard; Blue Lips or Skin (Cyanosis): Symptoms & Treatment; K Health (2020)
  3. P Pahal and A Goyal; Central and Peripheral Cyanosis: StatPearls Publishing LLC. (2021)
  4. M. Ushay; Cyanosis; Textbook of Pediatric Care (Chapter 136)
  5. D Passàli et al; Foreign body inhalation in children: an update. (2010)
  6. Mariateresa Sinelli et al; Early Neonatal SARS-CoV-2 Infection Manifesting With Hypoxemia Requiring Respiratory Support; American Academy of Pediatrics
  7. Cyanosis; Boston Children’s Hospital
  8. Cyanosis (Blue colouration of lips feet body): Diagnosis and Treatment; Narayana Health
  9. Cyanotic Heart Disease; Nicklaus Children’s Hospital
  10. Cyanotic heart disease; MedlinePlus
  11. Adebayo Adeyinka and Noah P. Kondamudi; Cyanosis: StatPearls Publishing LLC.
  12. Overview of cyanosis in the newborn.,pulmonary%20disorders%20(table%201)
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Dr. Neema Shrestha is a pediatrician with a special interest in the field of neonatology. She has an overall experience of five years working in the field. Currently working in Kathmandu, Nepal, she completed her MBBS from Kasturba Medical College, Manipal in 2008, Diploma in Child Health from D.Y. Patil University in 2011, MD from Nepal Medical College in full bio