Research-backed

hCG Blood Pregnancy Test: Procedure, Results And Accuracy

Image: Shutterstock

IN THIS ARTICLE

hCG tests involving blood and urine tests could help in detecting pregnancy. The hCG levels could be first detected in blood as early as six days of egg implantation and reach their peak in the first 14 to 16 weeks after your last menstrual period. Subsequently, they decline and remain stable for the rest of the pregnancy (1).

Read this MomJunction post to know about the hCG blood test, when to go for it, how to detect the results and the accuracy of the test.

What Is hCG Blood Test?

hCG blood tests help confirm pregnancy by checking the presence of the hCG hormone in blood. You can undergo these tests only at a clinic.

The two types of hCG blood pregnancy tests that you might have to take include:

  • Qualitative hCG test: It checks for the presence of hCG in your blood and gives either a positive or negative result (2).
  • Quantitative hCG test: It measures the amount of hCG in your blood. It might help determine the exact age of the fetus or detect pregnancy complications, such as miscarriage or ectopic pregnancy—a complication in which the embryo implants outside the uterus (3).

A quantitative hCG blood test is also referred to by other names, including:

  • Beta hCG blood test
  • Repeat quantitative beta-hCG test
  • Quantitative serial beta-hCG test
  • Quantitative blood pregnancy test

How Soon Can A Quantitative hCG Test Detect Pregnancy?

An hCG blood test might detect your pregnancy as early as six to eight days after ovulation (4). The result is more reliable if you take the test ten days after you miss your menstrual period (5).

How Accurate is The hCG Blood Test For Pregnancy?

Blood tests are about 99% accurate. They may give false-positive or false-negative results in rare cases. A small sample of blood is enough to detect the presence and level of hCG hormone. Also, hCG blood tests are more reliable than hCG urine tests as they can detect even low levels of hCG (6).

The factors that could affect the hCG blood test results could be (7):

  • Medications, especially fertility drugs
  • Presence of certain tumors (such as germ cell tumors)
  • Recent pregnancy loss

Why Do You Need An hCG Blood Test?

An hCG blood test is usually done for the following reasons (2) (3) (7):

  • To determine pregnancy
  • To know the fetal age
  • To diagnose abnormal pregnancies such as molar pregnancy and ectopic pregnancy
  • To detect a possible miscarriage
  • As part of a screening test for Down syndrome
  • To diagnose abnormal conditions (such as ovarian tumors) in non-pregnancy cases

What Are The Other Reasons For Performing Beta hCG Blood Test?

hCG is considered a tumor marker as it is present in some types of cancers. The conditions in which the hCG hormone is likely to be present include (8) (9).

  • Cancers of the ovaries and uterus
  • Trophoblastic tumor
  • Hydatidiform mole
  • Testicular cancer (in the case of men)

hCG levels are found to be elevated in the case of cancers of the lungs, liver, stomach, and pancreas too.

How Is The b-hCG Test Performed?

The test is similar to any typical blood test. It requires a small amount of blood drawn from the vein in the arm (called venipuncture) and requires no special preparation. However, you should inform your doctor if you are taking any drugs, herbal preparations, nutritional supplements, or homeopathic medicines as they might affect the results.

The test involves the following steps (8):

  1. The phlebotomist (a technician who collects blood samples) wraps an elastic band around the upper arm. This causes the veins to swell so that they are visible.
  1. The site (the area where the vein is visible and its surrounding region) is then cleaned with an antiseptic.
  1. A needle is gently inserted into the vein and the blood sample is collected in a vial.
  1. The elastic band and the needle are removed.
  1. The site is covered using a cotton gauze or an adhesive bandage to stop any excessive bleeding.
  1. The blood sample is sent to the laboratory for analysis.

Does hCG Blood Test Pose Any Risks?

There may not be any major risks of an hCG test. The effects might be momentary. Some of them are (7) (11):

  • Pain or a stinging sensation at the puncture site
  • Lightheadedness
  • Bleeding under the skin (hematoma)
  • Infection if the skin is broken

How To Read hCG Blood Test Results?

In a qualitative beta hCG test,

  • A positive result indicates that you are pregnant.
  • A negative result indicates that you are not pregnant (2).

In a quantitative beta hCG test,

The result is given as a number (in milli-international units per milliliter – mIU/mL) that indicates the concentration of hCG hormone in the blood. The levels rise rapidly during the first trimester, and then decline and become steady over the rest of the pregnancy. The levels may vary depending on your gestational age. Your doctor can explain what the specific levels mean in your pregnancy.

In a non-pregnant woman, the levels would be less than 3mIU/mL (12)

Weeks after the last menstrual period (LMP)Normal hCG range (mIU/mL)
35 – 72
410 – 708
5217 – 8,245
6152 – 32,177
74,059 – 153,767
831,366 – 149,094
959,109 – 135,901
1044,186 – 170,409
1227,107 – 201,165
1424,302 – 93,646
1512,540 – 69,747
168,904 – 55,332
178,240 – 51,793
189,649 – 55,271

Your healthcare provider will help you in interpreting the result.

A higher hCG level than the normal range may mean any of the following (3):

  • Multiple pregnancies (such as twins or triplets)
  • Uterine choriocarcinomas
  • Hydatidiform mole or molar pregnancy
  • Ovarian cancer

A lower hCG level than the normal range may mean any of the following (3):

  • Incomplete miscarriage
  • Fetal death
  • Ectopic pregnancy

hCG Blood Test Results: False Positives And False Negatives

It may be possible to get false results from an hCG test similar to urine or home pregnancy tests.

  • False-positive pregnancy test result: The test shows positive even though you are not pregnant. You may get a false-positive result if you are on any medications (containing hCG) or have certain cancers (7).
  • False-negative pregnancy test result: In this case, the test result shows negative, but you are pregnant. It may happen if the test is taken too early, before there is enough hCG produced in the blood. Medications or harmful habits such as smoking and drinking alcohol may also give a false-negative test result (13).

If the test shows negative, and if you think you are pregnant, the doctor might recommend the test again in a few days.

Frequently Asked Questions

  1. How much does a quantitative hCG blood test cost?

A quantitative blood test is more expensive than a home pregnancy or a urine test. The cost may vary depending on the doctor’s fee and laboratory fee. If covered in insurance, it is likely to be easy for you. The test is usually suggested for complicated pregnancies.

  1. How long does it take to get the results of the quantitative hCG test?

The time for the test may vary from lab to lab. While some may provide the results in a few hours, some might take two to three days.

hCG blood tests detect a pregnancy earlier than a urine test, and they measure the level of hCG that could be useful for tracking any medical condition.

See a doctor if you have any concerns about testing pregnancy early or if you have experienced any miscarriage or fetal abnormality. Your doctor may suggest either a qualitative blood serum test or an ultrasound depending on your condition.

References:

1. Human Chorionic Gonadotropin (HCG); Regents of the University of Michigan
2. HCG blood test – qualitative; U.S. National Library of Medicine, U.S. Department of Health and Human Services
3. HCG blood test – quantitative; U.S. National Library of Medicine, U.S. Department of Health and Human Services
4. Knowing if you are pregnant; Office of Women’s Health, U.S. Department of Health and Human Services
5. Pregnancy Test (hCG); Lab Tests Online; American Association for Clinical Chemistry
6. Pregnancy testing; Better Health Channel; Department of Health & Human Services, Victoria State Government, Australia
7. HCG (Blood); University of Rochester Medical Center
8. HCG in Blood Serum — Qualitative; The Regents of The University of California; University of California San Francisco
9. How Is Gestational Trophoblastic Disease Diagnosed; American Cancer Society
10. Testicular Cancer Tumor Markers; The Johns Hopkins University
11. HCG blood test  qualitative; Florida Agency for Health Care Administration
12. HCG – Pregnancy, Serum, Quantitative; University of Iowa Diagnostic Laboratories
13. Pregnancy; U.S. FDA