Lupus In Children: Symptoms, Causes, Treatment, And Prevention

Lupus In Children Symptoms Causes

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Lupus is a systemic autoimmune disease that occurs when the immune system attacks its own body different tissues and organs, such as the skin, joints, heart, brain, and kidneys. The condition affects ten in one million children per year. About 15 to 20% of lupus patients have childhood onset of the disease (1).

The pediatric onset of lupus may cause more severe illness and organ damage over time. The symptoms and flare-up of lupus can be managed with medications.

Read this post to know more about the types, causes, symptoms, diagnosis, and treatment of lupus in children and ways to prevent it. 

Types Of Lupus

Lupus can be of four types based on its clinical features and cause (2).

  • The systemic lupus erythematosus (SLE) is the most common type of lupus that affects the whole body system and multiple organs of the body.
  • The cutaneous lupus erythematosus (CLE) involves only the skin, and you may notice sores or rashes in the sun-exposed areas, such as the face, neck, scalp, arms, and legs. It is basically a butterfly type of rash on the face.
  • Drug-induced lupus is caused by the intake of certain drugs and usually disappears once the person stops taking the triggering medication.
  • Neonatal lupus is temporary lupus caused by autoantibodies from the mother reaching the baby through the placenta. It is seen in newborns and usually disappears within a few months without causing severe damages.

If your child had any past incidence of drug-induced lupus, let the doctor know before they prescribe medication. The doctor may prescribe drugs that do not cause drug-induced lupus. 

Causes Of Lupus In Children

The exact cause may not be known in many cases. However, the following factors may increase the risk of developing lupus in children (3).

  • Genetic factors
  • Viral infections
  • Medications, such as procainamide and hydralazine
  • Physical or emotional stress
  • Certain hormones, such as estrogen

Lupus could be a result of a combination of genetic and environmental factors. Girls tend to be at a higher risk due to the estrogen hormone. Nevertheless, some children may not develop the condition despite having the risk factors, while some may have lupus without any risk factors.

Signs And Symptoms Of Lupus In Children

Signs And Symptoms Of Lupus In Children

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The signs and symptoms may vary in each child, depending on the severity and affected organ or tissue. These may include (4):

  • Skin rashes on the body and face. Butterfly rash on face
  • Fever
  • Joint pain (Arthralgia)
  • Photosensitivity. Rashes developing on exposure to sun
  • Fatigue and tiredness. Muscle aches
  • Muscle aches
  • Oral, nasal, and throat sores
  • Swollen lymph nodes
  • Weight loss
  • Hair loss or alopecia
  • Tingling, pain, cold, and numbness on fingers or toes (Raynaud’s syndrome)
  • Increased infections
  • Anemia (low red blood cell count)
  • Seizures and other neurological symptoms
  • Kidney problems varying from low urine output, acute glomerulonephritis to renal failure
  • Inflammations, such as pericarditis, pleuritis, and peritonitis

These symptoms and signs can also be seen in other diseases. Consult a pediatrician for the exact diagnosis and treatment of lupus.

Diagnosis Of Lupus In Children

Lupus diagnosis can be suspected based on the symptoms and physical examination. The following tests are often ordered to confirm the diagnosis (5).

  • Antinuclear antibodies (ANA) in the blood
  • Blood cell count
  • Urinalysis
  • Kidney and liver function test
  • Skin and kidney biopsy

Doctors may order additional tests such as imaging tests, including MRI, CT, echocardiography, and chest X-ray, to determine organ involvement.

Your child may also be referred to a specialist, such as a dermatologist for cutaneous lupus or rheumatologist for joint problems, for evaluation or treatment based on the organs and tissues involved.

Treatment For Lupus In Children

There is no specific cure for lupus. However, symptoms can be managed with medications. The treatment options may vary based on the organs involved. The following medications are often prescribed to control common symptoms and reduce the severity of the disease (6).

  • Corticosteroids, such as prednisone, to reduce inflammatory reactions
  • NSAIDs (nonsteroidal anti-inflammatory drugs), such as ibuprofen and naproxen, for pain, fever, and swelling
  • Acetaminophen for pain
  • Antimalarial drugs, such as hydroxychloroquine, to reduce lupus flare-up as well as to reduce joint pains
  • Immunosuppressants, such as azathioprine and methotrexate, to reduce autoimmune reactions
  • Biologics, such as belimumab and rituximab, to minimize lupus symptoms

These drugs may cause some side effects, such as stomach upset and allergic reaction. Although some of them are available over-the-counter, taking them for a chronic condition without knowing the appropriate dosage could increase the risk of side effects.

Always seek medical consultation for long-term drug therapy for lupus. Doctors may add other medications in prescription to protect the stomach lining.

Prevention For Lupus In Children

Although all cases of lupus cannot be prevented, the following tips may prevent incidences of lupus in some children or rather reduce flareups (6).

  • Reduce stress
  • Get enough rest
  • Take part in regular physical activity
  • Stick to a healthy diet
  • Reduce sun exposure
  • Avoid lupus-causing drugs
  • Get vaccinated and practice hygiene measures to reduce viral infections

The above-mentioned measures may also prevent flare-ups in children with existing lupus symptoms. Lupus may persist for life, so your child requires follow-up visits and medications during a flare-up. You may contact their doctor sooner if you notice the recurrence of symptoms to begin immediate treatment and reduce the severity of the illness. Lupus is not a life threatening disease and can be easily managed with proper treatment and guidance.

Lupus can cause symptoms, such as skin rashes, that may lower the quality of life and affect a child’s mental well-being. Encourage your child to look beyond the symptoms of lupus and focus on other aspects of life, such as studies, friends, and family. You may encourage them to join local or online support groups and organizations. Adequate support, management steps, and treatment plans can help a child deal with lupus and minimize its interference with day-to-day life. 


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Dr. Mubina Agboatwalla

Dr. Mubina Agboatwalla is a well-known pediatrician, practicing paediatrics since the last 20 years in Karachi Pakistan. She is the head of the department of Pediatrics in Karachi Liaquat Hospital, as well as her private practice in three specialist clinics in Pediatrics. She is also a Public Health Specialist specializing in preventive health including nutrition, breastfeeding and infectious diseases especially... more

Dr Bisny T. Joseph

Dr. Bisny T. Joseph is a Georgian Board-certified physician. She has completed her professional graduate degree as a medical doctor from Tbilisi State Medical University, Georgia. She has 3+ years of experience in various sectors of medical affairs as a physician, medical reviewer, medical writer, health coach, and Q&A expert. Her interest in digital medical education and patient education made... more