Mesenteric Lymphadenitis In Children: Symptoms And Treatment

check_icon Research-backed

A widespread abdominal pain may indicate mesenteric lymphadenitis in children. It is the inflammation of the mesenteric lymph nodes, which are clusters of three or more lymph nodes in the right lower mesentery. The peritoneum fold (abdominal cavity membrane) that connects the intestines to the back of the abdominal wall is referred to as the mesentery.

While mesenteric lymphadenitis can occur at any age, it is more common in children (1). Therefore, if your child experiences significant abdominal pain, consult your child’s doctor since it could signify a problem that requires medical attention.

Read on to learn the various causes, symptoms, risk factors, and complications of mesenteric lymphadenitis and how it can be diagnosed, treated, and prevented in the pediatric population.

Signs And Symptoms Of Mesenteric Lymphadenitis In Children

Mesenteric lymphadenitis can be chronic or acute inflammation, depending on the microorganism causing it. Signs and symptoms of mesenteric lymphadenitis may include (2):

  • Abdominal pain on lower right side
  • Fever
  • Abdominal tenderness
  • Enlarged mesenteric lymph nodes (not palpable but diagnosed with ultrasound scan)
  • Nausea
  • Vomiting
  • Diarrhea

Widespread lower right quadrant abdominal pain is a common symptom of mesenteric lymphadenitis in most children. The above-mentioned signs and symptoms can also be seen in other diseases and may also vary in mesenteric lymphadenitis, depending on the cause.

Causes Of Mesenteric Lymphadenitis In Children

Viral infections are a major cause of mesenteric lymphadenitis in children. Viral gastrointestinal tract infections, such as stomach flu (viral gastroenteritis), may cause inflammation of the mesenteric lymph nodes.

The following conditions may also cause inflammation or enlargement of mesenteric lymph nodes (3).

Risk Factors And Complications Of Lymphadenitis In Children

The risk factors for mesenteric lymphadenitis can be similar to the risk factors for bacterial or viral gastroenteritis, such as the consumption of contaminated food and water. Children with diagnosed IBD or lymphoma may also have a high risk of lymphadenitis.

Complications of mesenteric lymphadenitis may include (4):

  • Dehydration due to electrolyte and water loss from diarrhea and vomiting
  • Peritonitis
  • Sepsis
  • Abscess
  • Arthralgia (joint pain)

When To See A Doctor

Abdominal pain is common in children and teens, and it can be hard to know when it requires medical attention. However, if your child has severe, sudden onset of abdominal pain, seek immediate medical care since this can even be the symptom of appendicitis. Abdominal pain with fever, diarrhea, or vomiting also requires medical care to avoid complications (5).

Diagnosis Of Mesenteric Lymphadenitis In Children

Pediatricians will perform a physical examination and also ask about the symptoms and medical history of your child. Depending on the findings from the history and physical exam, they may order blood tests and imaging tests to confirm the diagnosis of mesenteric lymphadenitis (6).

Blood tests could help confirm the presence and type of infection, and imaging tests such as abdominal ultrasound or a CT scan give a visualization of mesenteric lymph nodes.

Lifestyle And Home Remedies For Lymphadenitis

Mild mesenteric adenitis after stomach flu can be managed at home through the following ways (5).

  • Adequate rest to enhance recovery
  • Drink enough fluids to prevent dehydration
  • Warm moist heat application using washcloth over the abdomen may help ease pain and discomfort

Home remedies are enough to treat mild conditions since it is a self-resolving disease. However, seeking expert advice is always helpful to confirm the diagnosis and exclude other causes of abdominal pain in children.

Treatment For Mesenteric Lymphadenitis In Children

Treatment for mesenteric lymphadenitis depends on the underlying cause and severity of the disease. Treatment may include (7):

  • Supportive care with adequate hydration.
  • Mild and uncomplicated mesenteric lymphadenitis due to viral gastroenteritis can be self-limiting and completely resolves within a month or more.
  • Mild cases may not require any specific therapies, and symptoms can be treated by over-the-counter pain and fever medications, such as Tylenol (acetaminophen) and Advil or Motrin (ibuprofen). Aspirin should be avoided since it may cause Reye’s syndrome.
  • Complications such as suppuration, abscess, or peritonitis are managed with abdominal surgery (laparotomy) and antibiotics.

Although in many children, mesenteric lymphadenitis can be cured completely without specific management, a few children with severe infection and associated sepsis may require hospitalization and aggressive management. Untreated severe lymphadenitis can be life-threatening in children.

How To Prevent Mesenteric Lymphadenitis In Children?

Preventing bacterial and viral infections helps reduce the risk of mesenteric lymphadenitis in children. The following precautions may help reduce the risk of infectious diseases in children (8).

  • Wash hands with soap and water
  • Avoid close contact with sick people
  • Do not consume contaminated food and water

Mesenteric lymphadenitis in children can cause abdominal pain, fever, and abdominal tenderness. It is recommended to evaluate the sudden onset of severe abdominal pain in children than giving pain relievers since it may mask symptoms. It is the inflammation of lymph nodes attached to the intestines on the lower right side of the abdominal wall. Children with lymphoma, bacterial gastroenteritis, and inflammatory bowel diseases (IBD) are more prone to develop mesenteric lymphadenitis than others. If left unmanaged, it might complicate sepsis, peritonitis, and abscess formation. Symptomatic management, antibiotic therapy, or surgery is prescribed depending on the severity of the condition.

Frequently Asked Questions

1. Is mesenteric lymphadenitis serious?

Mesenteric lymphadenitis is seldom serious in children since it often resolves without complications. Although the abdominal pain can mimic an acute abdomen, it may not require emergency interventions, such as appendicitis or intussusception (9).

2. Can COVID-19 cause mesenteric lymphadenitis?

Children with COVID-19 gastrointestinal infections are reported to have mesenteric lymphadenopathy. The imaging tests confirmed the involvement of mesenteric lymphadenopathy in children presenting with abdominal pain. However, most developed severe illnesses require intensive care for COVID-19 symptoms before recovering from mesenteric lymphadenopathy (10).

3. How long does it take for mesenteric lymphadenitis to go away?

Most children can completely recover within four weeks or around. Usually, mild and uncomplicated cases of mesenteric lymphadenitis resolve without specific treatments (9).

Key Pointers

  • Mesenteric lymphadenitis is commonly seen in children and can occur due to a viral infection of the GI tract.
  • Nausea, fever, or pain in the lower right of the abdomen are a few symptoms they may experience.
  • The doctor may conduct a thorough physical examination and some blood tests to assess the condition.
  • Depending on the results, children may be recommended medications or surgical intervention.
  • Staying hydrated and warm compress may help manage the situation at home.


MomJunction's articles are written after analyzing the research works of expert authors and institutions. Our references consist of resources established by authorities in their respective fields. You can learn more about the authenticity of the information we present in our editorial policy.
1. Rossana Helbling, et al.; Acute Nonspecific Mesenteric Lymphadenitis: More Than “No Need for Surgery; The United States National Library of Medicine
2. Mesenteric Adenitis; Tameside And Glossop Integrated Care; Nhs Foundation Trust
3. What is Mesenteric Adenitis?; Keystone Medical Healthcare services
4. Megan Birkhold and Scott Langenburg; Is mesenteric adenitis a benign condition? Ischemic colitis secondary to mesenteric adenitis in a 12 year old; Sciencedirect; Journal of Pediatric Surgery Case Reports
5. Mesenteric lymphadenitis; NCH Baker Hospital Downtown and North Naples Hospital
6. Mesenteric adenitis; Women’s & Children’s Hospital
7. Mesenteric Lymphadenitis; OMICS International
8. Mesenteric Lymphadenitis; Cleaveland Clinic.
9. Mesenteric Lymphadenitis; St. Clair Health.
10. Sakura Noda, et al; Severe COVID-19 initially presenting as mesenteric adenopathy; National Library of Medicine
Was this information helpful?
The following two tabs change content below.

Dr Bisny T. Joseph

Dr. Bisny T. Joseph is a Georgian Board-certified physician. She has completed her professional graduate degree as a medical doctor from Tbilisi State Medical University, Georgia. She has 3+ years of experience in various sectors of medical affairs as a physician, medical reviewer, medical writer, health coach, and Q&A expert. Her interest in digital medical education and patient education made... more

Dr. Elna Gibson

(MBChB, MMed, Paeds)
Dr. Elna Gibson is a general pediatrician. She did her MBChB and specialization as a pediatrician in South Africa at the University of Pretoria. She obtained MMed Pediatrics (masters) with distinction in 1993. As a young specialist, Dr. Gibson spent some time in the Netherlands, and then settled in the Vaal Triangle where she has practiced for 25 years. She... more