Phenylephrine, an ingredient of over-the-counter (OTC) nasal decongestants, can also be used to control hypotension occurring during C-sections done under spinal anesthesia (1). However, researchers are not entirely sure of the safety and efficacy of using phenylephrine when pregnant.
Some studies show that using phenylephrine in the first trimester may cause congenital disabilities in the baby; however, other studies do not find any risk involved in its usage. Therefore, you should seek a doctor’s advice before using a nasal decongestant containing phenylephrine.
Read this post to know about phenylephrine in detail, including its side effects and safety during pregnancy.
Are Phenylephrine-containing Decongestants Safe During Pregnancy?
It is not clearly known if phenylephrine in oral decongestants can cross the placenta and affect the fetus. But its vasoconstricting property might constrict uterine blood vessels, which may cause birth defects. However, when administered intranasally, for localized effect, phenylephrine carries less risk than when given systemically (2).
Some studies state that the use of phenylephrine as a decongestant in the first trimester might slightly increase the risk of birth defects. However, a few other studies did not find anything to this effect (3).
Another case study supported the hypothesis that the use of phenylephrine as a nasal decongestant in the first trimester increased the risk of endocardial cushion defect (2). But it did not find any association of first-trimester exposure to phenylephrine and ear, eye defects, and club foot in the baby.
There are thus no adequate studies to prove if maternal use of phenylephrine during pregnancy could cause serious birth defects. A medical resource paper by the American Academy of Family Physicians states that decongestants should be used sparingly during pregnancy until further research is done (4). So, always check with your doctor before using a nasal decongestant containing phenylephrine.
Phenylephrine As A Vasopressor During Pregnancy
Phenylephrine (Vazculep) is also used to treat hypotension.
The US Food and Drug Administration (FDA) classified intravenous phenylephrine as a Pregnancy Category C drug. It states that there are no adequate studies to determine the safety of intravenous phenylephrine during pregnancy. So, your doctor would prescribe it only when the potential benefits outweigh the risks (5).
What Happens If You Take Too Much Phenylephrine?
Prolonged use or overdosing can worsen or may cause the return of your nasal decongestant (6).
What Are The Side Effects Of Phenylephrine?
Some of the common side effects of this drug are:
- Loss of appetite
- Tingling and redness under the skin
- Skin rash and itching
The following are some elaborate side effects of phenylephrine.
- Fast pounding and uneven heartbeat
- Dizziness and anxiety
- Weakness, fever, chills and body aches
- High blood pressure, seizures, headache, blurred vision (8)
If you experience side effects, then stop using the drug, and see a doctor.
What Are Some Of The OTC Drugs That Contain Phenylephrine?
Some of the brand names of oral drugs that contain phenylephrine are.
- Contac Cold and Flu (9)
- Tylenol Sinus Plus Headache (10)
- Mucinex Fast-Max Cold and Flu (11)
- Sudafed PE (12)
- Tylenol Cold and Flu Severe Day/Night (13)
- Codral Day and Night (14)
The following are some intranasal drugs that contain phenylephrine.
There are no adequate scientific studies to prove the safe use of the decongestant medication phenylephrine when pregnant. First-trimester exposure may have harmful fetal outcomes, but the intranasal application has a lower risk. Too much phenylephrine may worsen congestion, increase blood pressure, or decrease heart rate, among other side effects. Make sure you read product labels as several OTC preparations may contain this compound. It is advisable to always check with your doctor before using any OTC medication during pregnancy, as they may be harmful to you and your baby.
2. Wai-Ping Yau, et al., Use of Decongestants During Pregnancy and the Risk of Birth Defects; NCBI (2013)
3. Aida Erebara, et al.; Treating the common cold during pregnancy; NCBI(2008)
4. Jessica Servey, MD, Jennifer Chang, MD; Over-the-Counter Medications in Pregnancy; The American Academy of Family Physicians
5. Prescribing Information-Vazculep; The US Food and Drug Administration
6. Phenylephrine Nasal Spray; Medline Plus; U.S National Library of Medicine
7. A Justification for changing the current wording of the GSL classification of phenylephrine to include a cut-off point for solid dose products containing 10 mg or less of phenylephrine; Medsafe
8. Phenylephrine; Michigan Medicine; University of Michigan
9. Contac cold and flu day- acetaminophen and phenylephrine hydrochloride tablet; Dailymed
10. Tylenol Sinus Plus Headache Day; Dailymed
11. Mucinex Fast- Max Cold and Flu; Dailymed
12. Sudafed PE; Dailymed
13. Tylenol Cold+Flu Severe Day/Night; Dailymed
14. Codral Day & Night; Codral official website
15. Neo-synephrine Extra Strength; Dailymed
16. 4 Way Fast Acting; Dailymed