Neonatal Polycythemia: Causes, Symptoms And Treatment

polycythemia in newborn babies symptoms treatment

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Neonatal polycythemia is defined as either venous hematocrit or abnormally high hemoglobin levels above 65% and 22 g/dl, respectively. It is reported in 0.4% to 5% of healthy term neonates. The affected baby may not always show specific symptoms but occasionally have ruddy or dusky skin (1) (2).

In this condition, the excess red blood cells slow down or block blood flow into the tiny blood vessels. This may lead to tissue death due to lack of oxygen and affect the organs such as the kidneys, lungs, and brain (3). However, with timely intervention, this condition can be treated.

Keep reading as we discuss the causes, symptoms, and complications of polycythemia in babies.

Causes Of Polycythemia 

Neonatal polycythemia could be caused by any of the following factors, some of which could be due to conditions that develop before birth (3).

Symptoms Of Neonatal Polycythemia 

In newborns, the red blood cell levels peak at the second hour of life compared to the cord blood levels. The levels then plateau between two to four hours of life and return to the cord blood levels at 12 to 18 hours of life. It is essential to observe any changes, and the postnatal screening should be done carefully and at the right time (4).

The symptoms of neonatal polycythemia may vary from baby to baby, and in some, it can be asymptomatic. The common symptoms of polycythemia include (3)

  • Extreme sleepiness
  • Feeding problems
  • Seizures, jitteriness
  • Trouble breathing
  • Low blood sugar
  • Decrease urination
  • Newborn jaundice (2) (4) 

Diagnosis Of Polycythemia 

Your child’s doctor would observe the symptoms and order the following tests (3).

  • Hematocrit to count the number of red blood cells
  • Oxygen level test in the blood
  • Blood sugar test
  • Creatinine test
  • Urinalysis
  • Jaundice test

Once the doctor determines polycythemia in your baby, the treatment will be initiated.

Treatment For Polycythemia

The treatment for polycythemia is done in two ways for symptomatic and asymptomatic  polycythemia (1):

  • Conservative management with rehydration
  • Partial exchange transfusion (PET)

For asymptomatic infants with a red blood cell percentage of 60%–70%, conservative treatment with rehydration (increasing the fluid intake) is often sufficient.

For babies who present with the above symptoms, a partial exchange may be needed, in which a small volume of blood is removed from the neonate and replaced with normal saline.

Prognosis Of Polycythemia

Babies tend to respond positively to the treatment, and good results are seen in infants who receive treatment in the case of severe conditions.

Possible Complications Of Polycythemia

The common complications caused by polycythemia include:

  • Necrosis of the intestinal tissues
  • Diminishing fine motor skills
  • Kidney failure
  • Strokes
  • Seizures

Prevention Of Polycythemia

The prevention of polycythemia depends on the underlying cause. Studies suggest that early cord clamping and holding the baby at the level of introitus at the time of delivery might help prevent polycythemia. However, there are no significant statistical evidence to support this (4).

Polycythemia is a rare blood disorder found in newborns. It can be treated if the symptoms are identified early on. Infants born with this complication would return to normal after the treatment. However, if the polycythemia is due to underlying conditions such as genetic disorders or if the pregnancy was high risk and the mother has hypertension or diabetes, it is important to screen the baby for polycythemia.


MomJunction's articles are written after analyzing the research works of expert authors and institutions. Our references consist of resources established by authorities in their respective fields. You can learn more about the authenticity of the information we present in our editorial policy.
1. Bashir Abdrhman Bashir, and Suhair Abdrahim Othman; Neonatal polycythaemia; Sudanese Journal Of Paediatrics
2. Polycythemia – newborn; MedlinePlus
3. S Umit Sarici, Murat Ozcan and Demet Altun; Neonatal Polycythemia: A Review; ClinMed International Library
4. Polycythemia Vera in Children; Stanford Children’s Health


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Dr Bisny T. Joseph

Dr. Bisny T. Joseph is a Georgian Board-certified physician. She has completed her professional graduate degree as a medical doctor from Tbilisi State Medical University, Georgia. She has 3+ years of experience in various sectors of medical affairs as a physician, medical reviewer, medical writer, health coach, and Q&A expert. Her interest in digital medical education and patient education made... more