Prednisone For Kids: Side Effects, Dosage And Interactions

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Prednisone and its metabolite Prednisolone belong to a category of drugs called corticosteroids. These drugs work as immunosuppressants and anti-inflammatory agents (1). Prednisone is similar to the hormones produced by the body and has a variety of indications, including those for children.

In this post, MomJunctions tells you about the safety profile, usage, and other important attributes of prednisone for kids.

When Is Prednisone Prescribed For children?

Prednisone, also known by its brand name Rayos, is given to children for the following health issues.

  1. Asthma: If your child has asthma, then the doctor might prescribe prednisone to reduce the symptoms such as wheezing. It is also given during severe attacks of asthma for a short period to reduce inflammation and swelling of the airways (2).
  1. Inflammatory bowel syndrome (IBD): Corticosteroids, like prednisone, are prescribed for IBD, Crohn’s disease, and ulcerative colitis. It helps control inflammation in the case of IBD.
  1. Autoimmune diseases: Prednisone is prescribed for autoimmune diseases such as lupus, acquired autoimmune hemolytic anemia, dermatomyositis, arthritis, etc. In these diseases, the body’s immune system mistakenly attacks the body. Since corticosteroids act as immunosuppressants, they help in reducing the severity of the symptoms.
  1. Duchenne muscular dystrophy (DMD): Corticosteroids slow down the progression of muscle weakness, and help preserve muscle strength. They also help preserve the heart and breathing muscles (3).

Is Prednisone Safe For Children?

According to the US Food and Drug Administration (FDA), the efficacy and safety of prednisone in children are backed by well-established studies.

However, it observes that the effects of prolonged treatment with prednisone should be weighed against the clinical benefits. Children should be given the lowest effective dose to minimize the negative effects (1).

Some studies prove that prednisone is effective and safe in children to treat nephrotic syndrome and aggressive lymphomas and leukemia, severe asthma, and wheezing. A randomized study on 76 children with steroid-resistant nephrotic syndrome, who were treated with a combination of tacrolimus and low-dose prednisone was found safe and effective (4).

Prednisone should only be given to children when your doctor prescribes them. Never self-medicate as it can result in some serious consequences.

Prednisone Dosage For Children

Your doctor will prescribe the dosage based on your child’s body response and the severity of the condition.

There are certain dosage specific precautions to be taken while administering prednisone to children:

  • Prednisone should not be given on an empty stomach. If your child’s doctor has prescribed prednisone once every day, then the dose will be after a meal; for instance, after breakfast.
  • Only use the measuring device provided with the medicine, when using the liquid form of prednisone. Do not use kitchen spoons to measure the medicine.
  • While buying the medication, read the label carefully to make sure you are buying the correct strength prescribed by the doctor.
  • If you missed one dosage, then administer it when you remember. But if it’s almost time for the next dosage, then follow your original schedule. Do not administer two doses or double the dosage to make up for the missed dosage. If you have doubts regarding the same, then contact your doctor.
  • Vomiting or throwing up is a common side effect of this medicine, so always stay with your child until they swallow the medication. If the child vomits the medicine completely, then once the child calms down, give the same amount of medicine one more time. But, if the vomiting happens with the future doses as well, then talk to your doctor (5).

Side Effects Of Prednisone

A study conducted on 3,200 children stated that vomiting, behavioral changes, and sleep disturbances were the most frequent side effects seen during short-term corticosteroid therapy. However, the study also emphasized that the increased susceptibility to infection was the most serious adverse drug reaction, as this drug suppresses the body’s immune system (6).

The US FDA warns that the use of prednisone can affect the growth and development of children, so pediatric patients on long-term prednisone treatment should be monitored constantly. The adverse reactions of the drug are similar to those in adults.

Common short-term side effects of prednisone

  • Fluid retention
  • Alteration in glucose tolerance
  • Behavioral and mood changes
  • Increased appetite and weight gain
  • Mood changes
  • Roundness of the face
  • Slight increase in body hair, on the arms, legs, and neck
  • Headaches
  • Mild stomach aches
  • Mild acne, and dry skin (1) (3).

Long-term side effects of prednisone

Long-term usage of prednisone has certain side effects on children such as:

  • Osteoporosis
  • Stunted growth
  • Cataracts
  • Osteopenia (loss of protein and mineral content from the bones)
  • Cutaneous atrophy
  • Hypertension and psychosis
  • Adrenaline and immune suppression (7)

It is essential to discuss the extent of side effects before starting the therapy for your child. Your child’s doctor might prescribe the lowest possible dosage, which may still help with your child’s condition. Doctors usually prescribe prednisone only when the potential benefits outweigh the risks.

As there are possible side effects while using prednisone, your doctor may advise regular screening to monitor the functioning of the body functions and also to know the extent of the effect of the medicine on them. Some of the tests include:

  • Checking blood pressure
  • Urine screening
  • Lung-function test
  • Muscle-strength test
  • Calcium in bones
  • Eye check-up
  • Height and weight measurement (1) (3).

Ways To Cope With The Side Effects Of Prednisone

The side effects of prednisone are something you cannot avoid, but you can always take certain measures to help your child cope with them. Managing the side effects may also help minimize any long-term effects to some extent.

  • If your child is gaining weight due to increased appetite, limit calorie-laden food. You can limit the portion size while incorporating more fresh vegetables and fruits in the diet. Regular exercise can also help maintain weight.
  • Avoid giving your child foods with high sugar content, and add no salt to their food (8).
  • Taking prednisone with food may cause indigestion due to irritation of the stomach wall. Minimize the chances of discomfort by not giving spicy food to the child for the meal that precedes the dose. Also, talk to your doctor to suggest medications to protect your child’s stomach.
  • If your child is having trouble sleeping because of the medication, then it is best to give the medicine during the day time, so that the levels in the blood are low during night
  • It is advised to use prednisone at the lowest possible dose and least duration to reduce the risk of osteoporosis. Your doctor might also prescribe calcium and vitamin D supplements. Maintaining proper nutrition, in general, may also help the child cope with prednisone therapy better.
  • Studies proved that prednisone is 18 times less likely to affect the growth of your child than some other corticosteroids. You may be able to further reduce the extent of side effects by asking your child’s doctor about alternate-day dosage (10).

Note: Only alter the dosage days upon your doctor’s instructions, and never skip dosage on your own.

Prednisone Drug Interactions

When your child is on prednisone therapy, be alert towards other medications since prednisone could interact with other drugs to cause adverse reactions.

  1. Avoid giving over-the-counter drugs such as acetaminophen, aspirin, antacids, or cold medications. If it is a must, then consult your child’s doctor first.
  1. Certain medications should not be taken with prednisone, and if taken, the child has to be monitored. Consult your doctor before giving your child the following medicines.
    • Echinacea
    • Warfarin
    • Isoniazid
    • Cyclosporine
    • Furosemide
    • Certain antibiotics
    • Hydrochlorothiazide
    • Some vaccines and diabetes medicines
  1. If you are using any home remedies or herbal supplements, inform your doctor to know their safety.
  1. Avoid giving soft drinks, chocolate drinks, tea, or coffee to your child while taking this medicine (5).
  1. Avoid giving cough syrups containing alcohol. Consult your doctor to prescribe a nonalcoholic cough syrup (8).

General Precautions To Be Taken While Giving Prednisone To Kids

  1. Prednisone should only be given as per the prescribed dosage. Do not increase or decrease the dosage without consulting your child’s doctor.
  1. Never stop giving prednisone suddenly, as it can cause withdrawal symptoms.
  1. The drug suppresses the immune system and can make the body susceptible to infections. Maintain good hygiene by asking your child to wash their hands often. It is ideal for the child to stay away from people with infections, like cold and flu (11).
  1. If your kid is allergic to prednisone, then inform the doctor. Also, let your doctor know if your kid has any of the below conditions
  • High blood pressure
  • Kidney problems
  • Seizures
  • Diabetes
  • Thyroid problems
  • Tuberculosis (5)

Take care when your child is on prednisone therapy. Have a thorough discussion with your doctor and clear all your doubts before starting the therapy. Also, if you see any serious side effects or other adverse reactions, seek medical attention.

Share your experience with us by commenting in the section below.

This post is for informational purposes only and is not a replacement for a doctor’s consultation. Do not use any medication without talking to your doctor.


MomJunction's articles are written after analyzing the research works of expert authors and institutions. Our references consist of resources established by authorities in their respective fields. You can learn more about the authenticity of the information we present in our editorial policy.
1. Prescribing Information- Rayos; The US Food and Drug Administration
2. Prednisone for asthma; leaflet information; Medicines for Children
3. Corticosteroid Medicine; The Royal Children’s Hospital Melbourne
4. Chen HX, et al.; Efficacy and safety of tacrolimus and low-dose prednisone in Chinese children with steroid-resistant nephrotic syndrome; NCBI (2019)
5. Prednisone and Prednisolone; Nationwide Children’s Hospital
6. Fahad Aljebab, Imti Choonara, Sharon Conroy; Systematic review of the toxicity of short-course oral corticosteroids in children; British Medical Journal
7. Michael J Rieder;The child with multiple short courses of steroid therapy; NCBI(2003)
8. Pediatric Prednisone (Deltasone®) Uses and Side Effects; Children’s Hospital of Pittsburgh
9. Prednisolone; National Healthcare System
10. Dora Liu, et al.; A practical guide to the monitoring and management of the complications of systemic corticosteroid therapy; NCBI(2013)
11. Prednisone; Memorial Sloan Kettering Cancer Center

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Jenni Johnson

Jenni Johnson is a registered nurse, psychiatric nurse and midwife. She has been looking after new parents from her practice in Durban, South Africa for the last 20 years. Her ante and post-natal clinic set the foundation for parenting and is known to be available to parents at any time. Her passion is with the individual mother - each with... more

shreeja pillai

Shreeja holds a postgraduate degree in Chemistry and diploma in Drug Regulatory Affairs. Before joining MomJunction, she worked as a research analyst with a leading multinational pharmaceutical company. Her interest in the field of medical research has developed her passion for writing research-based articles. As a writer, she aims at providing informative articles on health and pharma, especially related to... more