Is It Safe To Take Prednisone While Breastfeeding?

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Prednisone is an immunosuppressantⁱXDrugs that reduce and control the body’s immune response and prevent it from attacking its cells or tissues. drug used to treat various ailments. However, it’s uncertain whether you can take Prednisone while breastfeeding.

Usually, if you have a fever or upset stomach, you might wait for these conditions to resolve on their own because taking medications while breastfeeding is not recommended. However, if you have a painful immune system-related disease during lactation, you may wonder about the use of Prednisone.

The National Transplantation Pregnancy Registry in the United States investigated 124 nursing mothers with transplants for 48 months and found no evidence of Prednisone harming the newborn. Is this proof that Prednisone is safe to take during lactation? This post provides an answer to this query and discusses the drug’s effects on lactating mothers.

What Is Prednisone?

Prednisone is a glucocorticoidⁱXA class of steroid hormones responsible for essential body functions, involved in the treatment of inflammatory and autoimmune diseases. medication mostly used to suppress the immune system and decrease inflammation in autoimmune disorders and conditions such as allergies, asthma, COPDⁱXChronic obstructive pulmonary disease, a lung disease that constricts the airway leading to coughing and suffocation. , eczema, and rheumatoid diseasesⁱXRelated to conditions affecting the joints, bones, muscles, and ligaments, such as arthritis. . Doctors prescribe prednisone to treat low corticosteroidⁱXA group of steroid hormones produced in the adrenal cortex that are used for treatments in synthetic form to reduce inflammation. levels and ensure optimum functioning of vital body processes.

Moms are usually apprehensive about taking corticosteroid while breastfeeding.

Is Prednisone Safe While Breastfeeding?

There is no scientific evidence to prove that prednisone is unsafe while breastfeeding. In fact, the American Academy of Pediatrics classifies prednisone as a drug usually compatible with breastfeeding.

If a nursing mother takes a small dose of prednisone, a negligible quantity of it enters breast milk. And this amount does not harm the baby or affect the mother’s milk production (1).

However, if the mother takes a high dose, then the higher drug content enters the breast milk. It would be at its peak in the mother’s milk at around one hour after its consumption. It is advisable to limit the drug dosage and avoid breastfeeding for four hours after taking medicine. Else, take the medication after nursing the baby for the last time in the day.

Point to consider

To reduce infant exposure to maternal medicine overdose, alternate between bottle and breast-feeding or express and discard breast milk when the drug is at its highest concentration (4).

What Is The Safe Dose Of Prednisone While Nursing?

A medical consultant is the right person to prescribe the safe dose of prednisone during the lactation period. He weighs the benefits against the potential risks associated with the drug to prescribe the specified dosage. An overdose or misuse of prednisone may lead to undesirable side-effects.

The initial dosage of prednisone is around 5mg/day, and doctors gradually increase the dosage as per the requirement.

Prednisolone, the active metabolite of prednisone, is secreted in human milk. Various reports suggest that prednisolone concentrations in human milk are 5 to 25% of maternal serum level (2). The percentage of the drug entering the milk depends on several factors and some of them are:

• Maternal dosage
• Breastfeeding frequency
• Maternal metabolism
• Frequency of prednisone consumption

If your intake is around 40mg every day, the rate of secretion lies between 20 to 106ng/mL. The maternal prednisone dose of less than 20mg/day has no adverse effects while nursing (3).

Prednisone Implications While Nursing

So far, prednisone therapy has not been associated with any short-term or long-term complications in babies. But the mother can develop side effects such as:

• Risk of developing hypertension
• Slow healing of wounds
• Weight gain

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• Increase in blood sugar levels
• Formation of nodular lesions or acne on the skin
• Osteopenia or osteoporosisⁱXA condition that causes the weakening of bones due to decreased bone mass and mineral density.
• Hair loss

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• Abnormalities in menstrual cycles

Some other common side-effects of prednisone include dizziness, depression, acne, insomnia, stomach upset, and headache.

Medium to large doses of depot corticosteroids injected into the joints may lead to a temporary reduction of milk production.

Dr. Laila Kaikavoosi, a UK-based general practitioner and hormone specialist, says, “Prednisone, a corticosteroid, can potentially disrupt hormonal balance by interfering with the intricate hormonal interplay crucial for lactation. Therefore, women using prednisone while breastfeeding should monitor their milk supply closely under proper medical supervision.”

Researchers have found that the prednisone intake during the 28th to 34th week of gestation might interfere with the secretion of prolactin, thereby delaying the production of breast milk. However, no change was observed in the flow or volume of milk once the lactation begins.

Monitor your little one for signs such as infection, oral thrush, or viral diseases. If you observe any, seek immediate medical guidance and stop consuming the medicine.

Follow the dosage directions and safety warnings given by your physician. Also, take your measures to minimize the drug’s effect on the baby.

How To Minimize The Risk Associated With Prednisone?

Here are a few considerations that you can adopt to reduce the rate of secretion of prednisone in your breast milk:

• Change the breastfeeding frequency and avoid nursing the baby for at least three-four hours after taking prednisone. You may pump and store the breast milk before taking the medicine, and feed this during the gap.

• Drink adequate water to ensure optimal metabolite-excretion.

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• Avoid the consumption of any other chemicals, synthetic compounds or drugs, as they may interfere with the ongoing medication.

• Prednisone may increase the risk of developing osteoporosis. Doctors recommend calcium and vitamin D supplements as they regulate the breast milk supply and protect you from the risk of developing osteoporosis.

• You may consider alternative drugs such as methylprednisolone and prednisolone during breastfeeding.

Quick tip

Prednisone can alter salt processing in the body, causing fluid retention. A low-salt diet can help reduce discomfort (5).

Natural Ways To Boost Your Immune System While Breastfeeding

Following some simple tips may help boost the natural functioning of your immune system and overall maternal health.

• Get enough rest to eliminate excess stress.

• Avoid alcohol and illicit drugs.

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• Eat healthy food including fresh vegetables, fruits, whole grains, and nuts.

• Catch some sun rays for 10-15 minutes daily.

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• Indulged in exercising regimes like yoga, walking, and Tai Chi.

Did you know?

Vitamin A is essential for a strong immune system. One medium sweet potato can fulfill breastfeeding moms’ daily vitamin A requirement (6).

Infographic: Conditions Where Prednisone May Be Implicated

Besides asthma, COPD, and rheumatoid diseases, there are several other conditions where you may be prescribed Prednisone. The conditions usually require the body’s immune responses to be suppressed to control their symptoms. The infographic below provides a list of some such health conditions.

Illustration: Momjunction Design Team

Image: Dall·E/MomJunction Design Team

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Dr. Priya ShashankIBCLC, BAMS, MHA, IYCF, CCE

Dr. Priya Shashank is a lactation consultant and childbirth educator, striving to bring about a change in the way childbirth and breastfeeding are perceived in India. She works with expecting couples to educate them about childbirth and the initial days with the baby, and helps new moms and babies settle down into breastfeeding routine comfortably. Working from Ludhiana in Punjab,...more

• Dr. Laila KaikavoosiMBBS, GP

  Dr. Laila Kaikavoosi graduated from King's College London Medical School in 1999. She completed her General Practice training in London and gained membership in the Royal College of General Practitioners in 2007. Dr. Kaikavoosi is a Diplomat of the Faculty of Reproductive and Sexual Health. She practiced and trained in teaching hospitals in the UK and USA.
  
  Dr. Laila Kaikavoosi graduated from King's College London Medical School in 1999. She completed her General Practice training in London and gained membership in the Royal College of General Practitioners in 2007. Dr. Kaikavoosi is a Diplomat of the Faculty of Reproductive and Sexual Health. She practiced and trained in teaching hospitals in the UK and USA.

shreeja pillaiMSc

Shreeja holds a postgraduate degree in Chemistry and diploma in Drug Regulatory Affairs from the University of Mumbai. Before joining MomJunction, she worked as a research analyst with a leading multinational pharmaceutical company. Her interest in the field of medical research has developed her passion for writing research-based articles. As a writer of more than two years experience, she aims...more

Rohit GarooBSc, MBA

Rohit Garoo is a writer-turned-editor with over 9 years of experience in content writing, editing, and content marketing. He did his bachelors in Science at St. Xavier's College, Hyderabad, and masters in Business Administration at Osmania University. Also, he holds a certificate in Developmental Psychology from The University of Queensland and loves to expand his knowledge through certifications in various...more

Vidya TadapatriMSc (Biotechnology)

Vidya did her post-graduation in Biotechnology from Osmania University, Hyderabad. Her interest in scientific research and writing made her pursue a career in writing, in which she now has over five years of experience. She has done certified biotechnology-related training programs under renowned organizations such as Centre For Cellular & Molecular Biology and Department of Biotechnology. Vidya writes health-based articles...more