10 Tips To Ease Pain After Vaccination In Babies

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According to the US Centers for Disease Control and Prevention (CDC), immunization is the proven safe method to protect babies from more than 14 serious childhood diseases (1).

Considering the fact that vaccines benefits outweigh the minor trouble including pain, you should always recommend vaccination and give parents some advice to reduce the discomfort after vaccination in infants.

In this post, we will discuss the possible side effects of vaccination, and tips to deal with pain.

Tips To Manage The Pain After Vaccination For Babies

Pain is a common after-effect of vaccination. Minimizing pain can help make vaccination less intimidating and stressful both for the infant and the parents. Babies exhibit lesser fear of needles and fewer healthcare avoidance behaviors on growing up when the pain from vaccination was managed better (2).

The following are some suggested tips to manage the pain after vaccination in infants.

1. Give some quiet time

The baby might be irritated and exhausted due to crying after the vaccine. Put the baby in a comfortable, temperature-controlled, and quiet room. Dress them in loose, comfortable, breathable clothes.

2. Hold the baby

Hold the baby close to yourself during and after vaccination. The baby might feel comfortable and less distressed with your skin contact. The CDC recommends holding and comforting the baby during vaccination to prevent the baby from moving his/her limbs (3).

3. Touch and soothe the baby

A study on determining the effective physical interventions to reduce pain after vaccination proved the “5 S” to be relaxing to the baby (4). The “5 S” are swaddling, side/stomach position, shushing, swinging, and sucking.

4. Distract the baby

Distraction is defined as the use of strategies to take an individual’s attention away from the procedure (2). A new toy, book, bubbles, or a simple game of peek-a-boo might help in distracting the baby, and making vaccination less stressful.

5. Breastfeed

Breastfeeding is believed to have an analgesic effect on babies due to several reasons like skin-to-skin contact, the soothing effect of sucking, being held by the mother, and the sweet taste of breastmilk. The mother may start breastfeeding the baby before the injection is administered and continue doing it during the vaccination procedure as well. However, if the mother and the baby are not comfortable with this arrangement, then feeding pumped milk through a bottle or formula feeding might also work (2).

6. Give sweet-tasting solutions

Administering sweet-tasting solutions might help in distracting and calming the baby. Studies have shown that giving a few drops of a sweet solution before the procedure, or giving a pacifier dipped in a sweet solution during the procedure, might ease the baby. However, this method is only recommended when the baby cannot be breastfed or formula-fed for some reason (2). Consult the doctor before choosing a sweet solution, like sugar syrup, for your baby. Never give honey to babies below the age of 12 months since it has the potential to cause gastrointestinal infection.

7. Apply cool pack

Applying cool packs of ice might help alleviate pain after vaccines. The application of a cool pack makes the skin numb, and thus reduces pain at the site of injection. Remember, not all infants might be able to tolerate the coolness of ice and might cry when touched with an ice pack. Discuss it with your pediatrician before using any cool packs for your baby (2).

8. Give more liquids

If you are exclusively breastfeeding the baby, then continue doing the same after vaccination too. But if you have already started giving solids to the baby, then they might consume only liquid and eat lesser than usual for the first 24 hours (3). In such a case, you can consider feeding a liquid diet of purees, soups, and mashed food. Feed the baby whatever he/she is comfortable in consuming for a day after vaccination.

9. Use topical anesthetics

Applying topical anesthetic agents might help in relieving pain from the vaccination. Topical anesthetics are available as rub-on gels as well as sprays. The gels might take an hour to show their effectiveness. Discuss with the pediatrician before using any over-the-counter (OTC) anesthetic agents (2).

10. Administer oral analgesics

The doctors might prescribe medicines like acetaminophen or ibuprofen to manage pain after vaccination. However, these medicines are given after considering the baby’s weight, age, and general health. Do not give any over-the-counter (OTC) medicines to the baby without consulting the doctor (5).

Other Possible After-Effects Of Vaccination

The pediatrician usually informs what reactions to expect after administering vaccines to the infant. The following are the common side effects of vaccinations (6).

  • Localized reactions like redness, swelling, and pain at the site of injection.
  • Fever due to vaccines starts within 24 hours of vaccine administration and may last for one or two days.
  • Delayed reactions of fever and rash after chickenpox and MMR shots. These reactions appear anytime between one to four weeks.
  • Very rarely, severe anaphylactic reactions to vaccines occur. They may start after two hours of vaccine administration. They need immediate medical attention.

If you suspect anything unusual in your baby’s health after vaccination, then contact the doctor immediately.

Frequently Asked Questions

1. How long does vaccination pain last in babies?

All local reactions to vaccines like swelling, redness, and pain start within 24 hours of vaccine administration. They last for three to five days. Some vaccines, like DtaP, can cause pain that may last for up to seven days (6).

2. Can I give paracetamol before vaccination?

It is not generally recommended to use paracetamol for babies who are going to be vaccinated. However, if the baby develops severe distress due to fever or pain after vaccination, giving paracetamol may be recommended after vaccination.

3. Is it safe to give a bath to my baby after vaccination?

Yes, it is okay to bathe the baby after vaccination. Remember to be gentle while cleaning the area where the injection was administered. If the baby has a fever due to vaccines, then you can give a sponge bath instead (7).

4. Do babies sleep more after vaccinations?

Some studies have shown that babies sleep more for a day after they have been vaccinated. A study observed that babies showed an increase in sleep for 24 hours, especially when they were vaccinated in the afternoon, after 1:30 PM (8). However, the case can vary for each baby. If you find the baby to be extremely lethargic, dull, and sleepy after vaccination, then see the doctor.

5. Should babies born prematurely receive vaccines at the general recommended age?

Yes, babies who are born prematurely should receive all the vaccination as per the normal vaccination schedule. Premature babies have a lower immunity as they receive fewer antibodies from the maternal placenta, and thus, must be vaccinated. If the baby weighs less than 2kg at birth, then vaccines like hepatitis B might be given after the baby achieves a weight of 2kg (9).

Vaccinating a baby is essential for a healthy life. Although vaccinations bring some pain along with it, the benefits of vaccines largely outweigh the risks. Mild to moderate pain after vaccination is normal, and by taking some measures, the vaccination experience can be made less painful for the baby. Always follow your doctor’s suggestion before deploying any pain-alleviating measures. If the pain and other symptoms of vaccinations last longer than expected, then promptly your baby’s healthcare provider.

Do you have any experiences to share? Let us know in the comment section below.


MomJunction's articles are written after analyzing the research works of expert authors and institutions. Our references consist of resources established by authorities in their respective fields. You can learn more about the authenticity of the information we present in our editorial policy.
1. Vaccinate Your Baby for Best Protection; Centers for Disease Control and Prevention
2. Anna Taddio et al., Reducing the pain of childhood vaccination: an evidence-based clinical practice guideline; U.S. National Library of Medicine
3. How to Hold Your Child During Vaccination; Centers for Disease Control and Prevention
4. Harrington JW et al., Effective analgesia using physical interventions for infant immunizations; U.S. National Library of Medicine
5. After the Shots; Immunize organization
6. Immunization Reactions; Seattle Children’s
7. My baby has some redness and pus on BCG injection site. How could I take care of this condition?; Family Health Service Hong Kong
8. Linda Franck et al., Infant Sleep After Immunization: Randomized Controlled Trial of Prophylactic Acetaminophen; U.S. National Library of Medicine
9. Arnaud Gagneur, Didier Pinquier, and Caroline Quach, Immunization of preterm infants; U.S. National Library of Medicine
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Dr. Nikolina Zdraveska

(PhD, MD )
Dr. Nikolina Zdraveska is a pediatrician, educator and a researcher, working at University Children Hospital in Skopje, Macedonia. She received her medical degree from the Medical Faculty of Skopje in her native Macedonia and completed Residency Training at University Children’s Hospital in Skopje. She is attending physician at the Department of Neonatology for ten years and is Assistant Professor at... more

Dr. Ritika Shah

Dr. Ritika Shah is a dental surgeon with more than seven years of clinical experience across various cities in India. During her clinical practice, pediatric dentistry was her particular area of interest, and she constantly thrived to inculcate the latest advancements in the field of dentistry into her practice. Dr. Shah's deep interest in the well-being of babies and children... more