Can You Take Tramadol While Pregnant?

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Tramadol belongs to the class of opioid analgesics used for pain relief. Using tramadol when pregnant may be questionable due to concerns about the safety of the growing fetus. Body aches and pain commonly occur during pregnancy due to various reasons such as restricted blood flow, expanding uterus, or lack of adequate hydration. Home remedies are usually effective in managing most of these pains, such as back pain, leg pain, and abdominal cramps. Ideally, you should avoid taking medications unless the alternative treatments fail to produce relief. This post tells you about tramadol, its safety during pregnancy, side effects, and precautions to take.

What Is Tramadol (Ultram)?

Tramadol is a prescription medication for treating moderate to severe pains caused by vascular, traumatic or inflammatory diseases. It belongs to a group of drugs known as opioid analgesics, which work by obstructing pain signals and change the way the brain and nervous system react to pain.

It is available in tablet and capsule forms and can be taken with or without food. It is available under the brand names Conzip and Ultram ER, and in combination with acetaminophen under the name Ultracet (1).

Can You Take Tramadol When Pregnant?

You should not take tramadol during pregnancy unless your doctor prescribes it. The US Food and Drug Administration has classified this drug under category C, which means animal trials have shown adverse effects on the fetus, and there are no well-controlled studies in humans.

Using tramadol during the early stages of pregnancy (vital time for the growth of the baby) has shown to cause congenital malformations and cardiovascular defects (2). Also, prolonged usage of tramadol even at a low dosage during pregnancy can cause neonatal opioid syndrome (the baby will be born with symptoms of opioid dependency) (3).

Labor or Delivery

Tramadol crosses the placenta and has the potential to cause respiratory depression and psycho-physiological effects in newborns. So, it is not recommended for use before or during labor. Usage of tramadol can prolong the labor by reducing the rate of cervical dilation (1).

What If You Have Already Taken Tramadol (Ultram) During Pregnancy?

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If you have been on tramadol before pregnancy or have taken it during pregnancy without prescription, let your doctor know about it.

What Are The Side Effects Of Taking Tramadol During Pregnancy?

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The most noticeable side effects of taking tramadol during pregnancy are dizziness, nausea, anxiety, drowsiness, and constipation. In some cases, there might also be breathing problems, skin rash, and seizures (4).

Can Tramadol Cause Miscarriage?

A few studies have suggested that withdrawal of opioids during pregnancy may cause sudden miscarriage or preterm birth (5). However, more research is needed.

Can Tramadol Increase The Chance Of The Baby Having Birth Defects?

Only a few studies have shown an increase in birth defects due to opioid medications. There is a very small or no confirmed risk of birth defects due to tramadol usage (6).

Does Tramadol Cause Other Pregnancy Complications?

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Studies evaluating opioid exposure during pregnancy suggested that exposure to tramadol during early pregnancy was associated with a statistically significant increased risk of clubfoot in the newborn (7).

The same study also reported that tramadol is associated with anencephaly (absence of cerebral hemispheres) and Spinal bifida (defects in the formation of the backbone) in the newborn.

Does Tramadol Cause Withdrawal Symptoms In The Baby After Birth?

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Intake of opioids (tramadol) during pregnancy can result in withdrawal symptoms in the newborn. The group of symptoms is described as neonatal abstinence syndrome (NAS) and appear in the first week of the baby’s life.

The symptoms include vomiting, irritability, and faster heart rate (8).

General Precautions To Follow While Taking Tramadol

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Take these steps before consuming tramadol:

  • Inform your doctor or pharmacist if you are allergic to any of the active ingredients in tramadol.
  • Tell your doctor about all the prescribed and non-prescribed medications you take regularly. Medications including anticoagulants and antidepressants interact with tramadol and can affect your health.
  • Inform your doctor about the herbal supplements and prenatal vitamins you might be taking.
  • If you have any chronic health conditions such as diabetes, asthma, breathing disorder or lung infections, tell your doctor about them.
  • Discuss your medical history, including any surgical treatment for any ailments including cancers and tumors.
  • Tramadol makes you drowsy. Do not drive cars after you take the drug.
  • Tramadol medication should not be stopped abruptly as it may cause withdrawal symptoms, always consult your doctor and reduce the dosage gradually.

Tramadol is a prescription-based opioid painkiller. Some researchers suggest that using tramadol while pregnant can have side effects on the growth and development of the fetus and may lead to miscarriage or preterm labor. Hence, tramadol should not be used during pregnancy unless prescribed by the treating gynecologist. The doctor will prescribe tramadol only if the benefits outweigh the risks. If you are experiencing any painful health conditions, consult a chronic pain specialist, who is an expert in assessing and prescribing medications during pregnancy.

Infographic: Precautions For Taking Tramadol In Pregnancy

Although Tramadol is used to treat moderate to chronic pain caused by inflammatory diseases, avoid the medication in the initial stages of pregnancy. However, you may take the drug in the later stages, only after your doctor’s approval. Follow the precautions mentioned in the infographic below to prevent its adverse effects.

precautions for taking tramadol in pregnancy [infographic]
Illustration: MomJunction Design Team


MomJunction's articles are written after analyzing the research works of expert authors and institutions. Our references consist of resources established by authorities in their respective fields. You can learn more about the authenticity of the information we present in our editorial policy.
1. Tramadol information; Postmarket drug safety information for patients and providers; US Food & Drug Administration.
2. Kallen B, Reis M; Use of tramadol in early pregnancy and congenital malformation risk; US National Library of Medicine National Institutes of Health (2015).
3. Ultram ER highlights of prescribing information; US Food & Drug Administration.
4. Tramadol hydrochloride- highlights of prescribing information; US National Library of Medicine.
5. Eung Don Kim, et al.; Guidelines for prescribing opioids for chronic non-cancer pain in Korea; US National Library of Medicine National Institutes of Health (2107).
6. Masha M. Yazdy; Rishi J. Desai; Susan B. Brogly; Prescription opioids in pregnancy and birth outcomes: a review of the literature; US National Library of Medicine National Institutes of Health
7. Jennifer N.Lind,; Maternal use of opioids during pregnancy and congenital malformations: a systematic review; Pediatrics- Official Journal Of The American Academy Of Pediatrics
8. S. Hartenstein,; Neonatal abstinence syndrome (NAS) after intrauterine exposure to tramadol; Academia



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